Abstract Aims To systematically assess the worldwide prevalence of nurse turnover and discuss its influencing factors. Design Systematic review and meta‐analysis. Methods PubMed, the Cochrane Library, Web of Science, CINAHL, China Knowledge Resource Integrated Database, Wanfang Database were searched from their commencement date to 25 March 2021. Two authors independently reviewed the studies. Stata 15.0 software package was used for statistical analysis, with estimates of data on the prevalence of nurse turnover using a random‐effects model. This review was performed according to the Joanna Briggs Institute (JBI) manual for evidence synthesis and the Preferred Reporting Items for Systematic Review and Meta‐Analysis (PRISMA) Statement. PROSPERO Registration Number:CRD42020208873. Results A total of 15 studies covering 852,317 nurses were included in the analyses. The pooled prevalence of nurse turnover was 18% (95% CI: 11% to 26%, I2 = 99.86%, p