دورية أكاديمية
Consumption of Non-Nutritive Sweetener, Acesulfame Potassium Exacerbates Atherosclerosis through Dysregulation of Lipid Metabolism in ApoE−/− Mice
| العنوان: | Consumption of Non-Nutritive Sweetener, Acesulfame Potassium Exacerbates Atherosclerosis through Dysregulation of Lipid Metabolism in ApoE−/− Mice |
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| المؤلفون: | Cheng-Hsin Lin, Hung-Yuan Li, Shu-Huei Wang, Yue-Hwa Chen, Yang-Ching Chen, Hung-Tsung Wu |
| المصدر: | Nutrients, Vol 13, Iss 11, p 3984 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Nutrition. Foods and food supply |
| مصطلحات موضوعية: | acesulfame potassium, apolipoprotein E, atherosclerosis, dysregulation, lipid metabolism, Nutrition. Foods and food supply, TX341-641 |
| الوصف: | Obesity is associated with the risk of cardiovascular disease, and non-nutritive sweetener, such as acesulfame potassium (AceK) has been used to combat obesity. However, the effects of AceK on cardiovascular disease are still unclear. In this study, high cholesterol diet (HCD)-fed ApoE−/− mice had dysregulated plasma lipid profile, and developed atherosclerosis, determined by atherosclerotic plaque in the aorta. Supplement of AceK in HCD worsened the dyslipidemia and increased atherosclerotic plaque, as compared with HCD-fed ApoE−/− mice. Since treatment of AceK in RAW264.7 macrophages showed no significant effects on inflammatory cytokine expressions, we then investigated the impacts of AceK on lipid metabolism. We found that AceK consumption enhanced hepatic lipogenesis and decreased β-oxidation in ApoE−/− mice. In addition, AceK directly increased lipogenesis and decreased β-oxidation in HepG2 cells. Taken together, a concurrent consumption of AceK exacerbated HCD-induced dyslipidemia and atherosclerotic lesion in ApoE−/− mice, and AceK might increase the risk of atherosclerosis under HCD. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 13113984 2072-6643 |
| Relation: | https://www.mdpi.com/2072-6643/13/11/3984; https://doaj.org/toc/2072-6643 |
| DOI: | 10.3390/nu13113984 |
| URL الوصول: | https://doaj.org/article/e344a676d2c1416bb06f8054549ff4fb |
| رقم الأكسشن: | edsdoj.344a676d2c1416bb06f8054549ff4fb |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 13113984 20726643 |
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| DOI: | 10.3390/nu13113984 |