دورية أكاديمية
The Impact of Variations in the Expression of Dicer on Pediatric Acute Lymphoblastic Leukemia
| العنوان: | The Impact of Variations in the Expression of Dicer on Pediatric Acute Lymphoblastic Leukemia |
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| المؤلفون: | Mahbobeh Hajirostamlou, saeid ghorbian |
| المصدر: | Journal of Advanced Biomedical Sciences, Vol 13, Iss 3, Pp 223-233 (2023) |
| بيانات النشر: | Fasa University of Medical Sciences, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Public aspects of medicine |
| مصطلحات موضوعية: | rnase iii endonucleases, dicer gene, pediatric acute lymphocytic leukemia, gene expression, Public aspects of medicine, RA1-1270 |
| الوصف: | Background & Objective: Dicer a member of the RNase III endonucleases has a crucial function in the development of miRNAs that affects gene expression in different kinds of cancers. The present research focused on examining the expression level of Dicer and its relation with clinicopathological features in children with Acute Lymphoblastic Leukemia (ALL) among the population in the northwest region of Iran. Materials & Methods: In a case-control study, 140 samples (70 patients and 70 healthy controls of similar age and sex rates) from 2019 to 2021 were included in the Dicer mRNA expression levels assessment. Quantitative Real-Time PCR analyses were utilized to determine expression levels of Dicer in samples and the demographic and clinicopathologic features and the relationship of these variables were evaluated. Results: Average Dicer expression Dct values were 2.8267 and up-regulated compared to healthy samples (P=0.000). No significant relationships have been found among gene expression, demographical and clinicopathological parameters. Also, demographical and clinicopathological factors were not correlated with the mRNA expression level of the gene except age (r=0.148, P=0.001). Conclusion: The current research shows that the expression of Dicer is significantly up-regulated in ALL patients, which suggests that it could have a vital function in ALL pathology. It will also theoretically be seen in the potential as a new intervention objective for ALL cases. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2228-5105 2783-1523 |
| Relation: | http://jabs.fums.ac.ir/article-1-2972-en.pdf; https://doaj.org/toc/2228-5105; https://doaj.org/toc/2783-1523 |
| URL الوصول: | https://doaj.org/article/3462d5fd0611455b96babb0499c7587a |
| رقم الأكسشن: | edsdoj.3462d5fd0611455b96babb0499c7587a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22285105 27831523 |
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