دورية أكاديمية
Cell-Based Therapy and Genome Editing as Emerging Therapeutic Approaches to Treat Rheumatoid Arthritis
| العنوان: | Cell-Based Therapy and Genome Editing as Emerging Therapeutic Approaches to Treat Rheumatoid Arthritis |
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| المؤلفون: | Vitaly Chasov, Irina Ganeeva, Ekaterina Zmievskaya, Damir Davletshin, Elvina Gilyazova, Aygul Valiullina, Emil Bulatov |
| المصدر: | Cells, Vol 13, Iss 15, p 1282 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Cytology |
| مصطلحات موضوعية: | rheumatoid arthritis, microRNA, CRISPR-Cas9, mesenchymal stem cell, CAR-T cells, Cytology, QH573-671 |
| الوصف: | Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the joints. Although much remains unknown about the pathogenesis of RA, there is evidence that impaired immune tolerance and the development of RA are related. And it is precisely the restoration of immune tolerance at the site of the inflammation that is the ultimate goal of the treatment of RA. Over the past few decades, significant progress has been made in the treatment of RA, with higher rates of disease remission and improved long-term outcomes. Unfortunately, despite these successes, the proportion of patients with persistent, difficult-to-treat disease remains high, and the task of improving our understanding of the basic mechanisms of disease development and developing new ways to treat RA remains relevant. This review focuses on describing new treatments for RA, including cell therapies and gene editing technologies that have shown potential in preclinical and early clinical trials. In addition, we discuss the opportunities and limitations associated with the use of these new approaches in the treatment of RA. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 13151282 2073-4409 |
| Relation: | https://www.mdpi.com/2073-4409/13/15/1282; https://doaj.org/toc/2073-4409 |
| DOI: | 10.3390/cells13151282 |
| URL الوصول: | https://doaj.org/article/346e936d826c4b19909f0fb9811c0c36 |
| رقم الأكسشن: | edsdoj.346e936d826c4b19909f0fb9811c0c36 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 13151282 20734409 |
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| DOI: | 10.3390/cells13151282 |