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Evaluation of classical swine fever E2 (CSF-E2) subunit vaccine efficacy in the prevention of virus transmission and impact of maternal derived antibody interference in field farm applications

التفاصيل البيبلوغرافية
العنوان: Evaluation of classical swine fever E2 (CSF-E2) subunit vaccine efficacy in the prevention of virus transmission and impact of maternal derived antibody interference in field farm applications
المؤلفون: Jing-Yuan Chen, Chi-Ming Wu, Zeng-Weng Chen, Chih-Ming Liao, Ming-Chung Deng, Min-Yuan Chia, Chienjin Huang, Maw-Sheng Chien
المصدر: Porcine Health Management, Vol 7, Iss 1, Pp 1-14 (2021)
بيانات النشر: BMC, 2021.
سنة النشر: 2021
المجموعة: LCC:Animal culture
LCC:Veterinary medicine
مصطلحات موضوعية: Classical swine fever, CSF-E2 subunit and live attenuated CSF vaccine, Maternally derived antibody, Saliva monitoring, Viral RNA detection, Vaccination-challenge-cohabitation trial, Animal culture, SF1-1100, Veterinary medicine, SF600-1100
الوصف: Abstract Background Classical swine fever (CSF) is one of the most devastating pig diseases that affect the swine industry worldwide. Besides stamping out policy for eradication, immunization with vaccines of live attenuated CSF or the CSF-E2 subunit is an efficacious measure of disease control. However, after decades of efforts, it is still hard to eliminate CSF from endemically affected regions and reemerging areas. Most of previous studies demonstrated the efficacy of different CSF vaccines in laboratories under high containment conditions, which may not represent the practical performance in field farms. The inadequate vaccine efficacy induced by unrestrained factors may lead to chronic or persistent CSF infection in animals that develop a major source for virus shedding among pig populations. In this study, a vaccination-challenge-cohabitation trial on specific-pathogen-free (SPF) pigs and long-term monitoring of conventional sows and their offspring were used to evaluate the efficacy and the impact of maternally derived antibody (MDA) interference on CSF vaccines in farm applications. Results The trials demonstrated higher neutralizing antibody (NA) titers with no clinical symptoms and significant pathological changes in the CSF-E2 subunit vaccine immunized group after CSFV challenge. Additionally, none of the sentinel pigs were infected during cohabitation indicating that the CSF-E2 subunit vaccine could provoke adequately acquired immunity to prevent horizontal transmission. In field farm applications, sows immunized with CSF-E2 subunit vaccine revealed an average of higher and consistent antibody level with significant reduction of CSF viral RNA detection via saliva monitoring in contrast to those of live attenuated CSF vaccine immunized sows possessing diverse antibody titer distributions and higher viral loads. Furthermore, early application of the CSF-E2 subunit vaccine in 3-week-old piglets illustrated no MDA interference on primary immunization and could elicit consistent and long-lasting adequate antibody response suggesting the flexibility of CSF-E2 subunit vaccine on vaccination program determination. Conclusions The CSF-E2 subunit vaccine demonstrated significant efficacy and no MDA interference for immunization in both pregnant sows and piglets. These advantages provide a novel approach to avoid possible virus shedding in sow population and MDA interference in piglets for control of CSF in field farm applications.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2055-5660
Relation: https://doaj.org/toc/2055-5660
DOI: 10.1186/s40813-020-00188-6
URL الوصول: https://doaj.org/article/34800d0d916048a6996a2b46b2926839
رقم الأكسشن: edsdoj.34800d0d916048a6996a2b46b2926839
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20555660
DOI:10.1186/s40813-020-00188-6