دورية أكاديمية
Lower serum cystatin C level predicts poor functional outcome in patients with hypertensive intracerebral hemorrhage independent of renal function
| العنوان: | Lower serum cystatin C level predicts poor functional outcome in patients with hypertensive intracerebral hemorrhage independent of renal function |
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| المؤلفون: | Yongfang Zhou, Wentao Dong, Likun Wang, Siying Ren, Weiqing Wei, Guofeng Wu |
| المصدر: | The Journal of Clinical Hypertension, Vol 25, Iss 1, Pp 86-94 (2023) |
| بيانات النشر: | Wiley, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: | cystatin C, estimated glomerular filtration rate, functional outcome, hypertensive intracerebral hemorrhage, neuroprotective effect, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Abstract We explored the association between the serum level of cystatin C (CysC) at admission and short‐term functional outcome in patients with hypertensive intracerebral hemorrhage (HICH) without chronic kidney disease (CKD). A total of 555 patients with HICH were consecutively recruited after admission and were followed‐up for 3 months after admission. The primary outcome was poor functional outcome (modified Rankin Scale [mRS] score ≥ 3). The median serum CysC level in our cohort was 1.03 mg/L (interquartile range, .89–1.20). Patients were categorized into four groups according to the serum CysC quartiles. Multivariate logistic regression analysis revealed a negative association between serum CysC and poor functional outcome at 3‐month follow‐up (quartile [Q]1 vs. Q4: adjusted odds ratio [OR] = .260, 95% confidence interval [CI] = .098, .691, p < .001). The negative association between serum CysC and poor functional outcome at 3 months was more pronounced in subgroups with smaller hematoma volume (≤ 30 mL), and absence of secondary intraventricular hemorrhage (IVH). Addition of serum CysC to a model containing conventional risk factors improved the model performance with net reclassification index (NRI) of .426% (p < .001) and integrated discrimination improvement (IDI) of .043% (p < .001) for poor functional outcome. Serum CysC was found to be a negative predictor of poor short‐term functional outcome in HICH patients independent of renal function. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1751-7176 1524-6175 |
| Relation: | https://doaj.org/toc/1524-6175; https://doaj.org/toc/1751-7176 |
| DOI: | 10.1111/jch.14609 |
| URL الوصول: | https://doaj.org/article/dd348060e076483ba7dd410940df1d4d |
| رقم الأكسشن: | edsdoj.348060e076483ba7dd410940df1d4d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17517176 15246175 |
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| DOI: | 10.1111/jch.14609 |