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Gene family innovation, conservation and loss on the animal stem lineage

التفاصيل البيبلوغرافية
العنوان: Gene family innovation, conservation and loss on the animal stem lineage
المؤلفون: Daniel J Richter, Parinaz Fozouni, Michael B Eisen, Nicole King
المصدر: eLife, Vol 7 (2018)
بيانات النشر: eLife Sciences Publications Ltd, 2018.
سنة النشر: 2018
المجموعة: LCC:Medicine
LCC:Science
LCC:Biology (General)
مصطلحات موضوعية: choanoflagellates, Urmetazoan, innate immunity, ancestral gene content, transcriptome, Medicine, Science, Biology (General), QH301-705.5
الوصف: Choanoflagellates, the closest living relatives of animals, can provide unique insights into the changes in gene content that preceded the origin of animals. However, only two choanoflagellate genomes are currently available, providing poor coverage of their diversity. We sequenced transcriptomes of 19 additional choanoflagellate species to produce a comprehensive reconstruction of the gains and losses that shaped the ancestral animal gene repertoire. We identified ~1944 gene families that originated on the animal stem lineage, of which only 39 are conserved across all animals in our study. In addition, ~372 gene families previously thought to be animal-specific, including Notch, Delta, and homologs of the animal Toll-like receptor genes, instead evolved prior to the animal-choanoflagellate divergence. Our findings contribute to an increasingly detailed portrait of the gene families that defined the biology of the Urmetazoan and that may underpin core features of extant animals.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2050-084X
Relation: https://elifesciences.org/articles/34226; https://doaj.org/toc/2050-084X
DOI: 10.7554/eLife.34226
URL الوصول: https://doaj.org/article/3482056d20df4bde9a579d49973bfc59
رقم الأكسشن: edsdoj.3482056d20df4bde9a579d49973bfc59
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:2050084X
DOI:10.7554/eLife.34226