دورية أكاديمية
Mechanisms of esophageal stricture after extensive endoscopic resection: a transcriptomic analysis
| العنوان: | Mechanisms of esophageal stricture after extensive endoscopic resection: a transcriptomic analysis |
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| المؤلفون: | Maximilien Barret, Ludivine Doridot, Morgane Le Gall, Frédéric Beuvon, Sébastien Jacques, Anna Pellat, Arthur Belle, Einas Abou Ali, Marion Dhooge, Sarah Leblanc, Marine Camus, Carole Nicco, Romain Coriat, Stanislas Chaussade, Frédéric Batteux, Frédéric Prat |
| المصدر: | Endoscopy International Open, Vol 11, Iss 02, Pp E149-E156 (2023) |
| بيانات النشر: | Georg Thieme Verlag KG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Diseases of the digestive system. Gastroenterology |
| مصطلحات موضوعية: | Diseases of the digestive system. Gastroenterology, RC799-869 |
| الوصف: | Background and study aims Esophageal stricture is the most frequent adverse event after endoscopic resection for early esophageal neoplasia. Currently available treatments for the prevention of esophageal stricture are poorly effective and associated with major adverse events. Our aim was to identify transcripts specifically overexpressed or repressed in patients who have developed a post-endoscopic esophageal stricture, as potential targets for stricture prevention. Patients and methods We conducted a prospective single-center study in a tertiary endoscopy center. Patients scheduled for an endoscopic resection and considered at risk of esophageal stricture were offered inclusion in the study. The healthy mucosa and resection bed were biopsied on Days 0, 14, and 90. A transcriptomic analysis by microarray was performed, and the differences in transcriptomic profile compared between patients with and without esophageal strictures. Results Eight patients, four with esophageal stricture and four without, were analyzed. The mean ± SD circumferential extension of the mucosal defect was 85 ± 11 %. The transcriptomic analysis in the resection bed at day 14 found an activation of the interleukin (IL)-1 group (Z score = 2.159, P = 0.0137), while interferon-gamma (INFγ) and NUPR1 were inhibited (Z score = –2.375, P = 0.0022 and Z score = –2.333, P = 0.00131) in the stricture group. None of the activated or inhibited transcripts were still significantly so in any of the groups on Day 90. Conclusions Our data suggest that IL-1 inhibition or INFγ supplementation could constitute promising targets for post-endoscopic esophageal stricture prevention. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2364-3722 2196-9736 |
| Relation: | https://doaj.org/toc/2364-3722; https://doaj.org/toc/2196-9736 |
| DOI: | 10.1055/a-2000-8801 |
| URL الوصول: | https://doaj.org/article/c348adbe55d4498dbad17c51867c361c |
| رقم الأكسشن: | edsdoj.348adbe55d4498dbad17c51867c361c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23643722 21969736 |
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| DOI: | 10.1055/a-2000-8801 |