دورية أكاديمية
Bone Health in Rheumatoid Arthritis: What Can Studies of Bone Microarchitecture Tell Us?
| العنوان: | Bone Health in Rheumatoid Arthritis: What Can Studies of Bone Microarchitecture Tell Us? |
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| المؤلفون: | Hannah Morgan, Chris Chan, Michael Clynes, Karen Jameson, Chris Holroyd, Cyrus Cooper, Kate Ward, Mark Edwards, Elaine Dennison |
| المصدر: | European Medical Journal Rheumatology, Pp 91-99 (2020) |
| بيانات النشر: | European Medical Journal, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Diseases of the musculoskeletal system |
| مصطلحات موضوعية: | Diseases of the musculoskeletal system, RC925-935 |
| الوصف: | Introduction: Rheumatoid arthritis (RA) is associated with changes in skeletal health, including increased risk of fracture. This study used a novel technique, high-resolution quantitative CT (HRpQCT), to assess bone microarchitecture in patients with RA. Methods: There were 59 patients (female: 41; male: 18) with RA recruited. They underwent dual energy X-ray absorptiometry and HRpQCT of the radius and tibia. The questionnaire information included age, sex, BMI, disease duration, comorbidities, medication use, smoking and alcohol consumption, rheumatoid factor (RF) or cyclic citrullinated peptide (CCP) status, and disease activity. HRpQCT results were compared with published estimated age and sex-specific values. Results: There were 55 patients (female: 39; male: 16) who had either radial or tibial scans available. The mean age was 55.8 (standard deviation [SD]: 12.6) years and median disease duration was 11.4 years (interquartile range [IQR]: 6.3–19.4). Mean BMI was 27.2 (SD: 5.8). Forty-nine (90.7%) participants were RF or CCP positive, with disease severity ranked as severe in 33 (61.1%) patients and moderate in 20 (37.0%). Fifteen participants (27.8%) had previously taken steroids and 47 (85.5%) were receiving tumour necrosis factor inhibitor (TNF-i) medication. Radial trabecular number and density were lower than expected, and trabecular separation was greater than expected (pl ess than 0.05), though tibial results were similar (p lower than 0.10 for trabecular number and separation). No difference in cortical values reached statistical significance in this sample. Previous use of steroids was associated with greater radial periosteal circumference (p lower than 0.05, adjusted for sex) and use of TNF-i agents was associated with lower radial total and trabecular area (p lower than 0.05, adjusted for sex). Conclusion: Trabecular bone microarchitecture differences were observed among patients with RA. Further studies with larger numbers of participants are needed. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2056-6395 35099194 |
| Relation: | https://www.emjreviews.com/rheumatology/article/bone-health-in-rheumatoid-arthritis-what-can-studies-of-bone-microarchitecture-tell-us/; https://doaj.org/toc/2056-6395 |
| DOI: | 10.33590/emjrheumatol/20-00064 |
| URL الوصول: | https://doaj.org/article/cac350991943487aaccfde4542e4fa5c |
| رقم الأكسشن: | edsdoj.350991943487aaccfde4542e4fa5c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20566395 35099194 |
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| DOI: | 10.33590/emjrheumatol/20-00064 |