دورية أكاديمية
Distinct ipRGC subpopulations mediate light’s acute and circadian effects on body temperature and sleep
العنوان: | Distinct ipRGC subpopulations mediate light’s acute and circadian effects on body temperature and sleep |
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المؤلفون: | Alan C Rupp, Michelle Ren, Cara M Altimus, Diego C Fernandez, Melissa Richardson, Fred Turek, Samer Hattar, Tiffany M Schmidt |
المصدر: | eLife, Vol 8 (2019) |
بيانات النشر: | eLife Sciences Publications Ltd, 2019. |
سنة النشر: | 2019 |
المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
مصطلحات موضوعية: | circadian, Suprachiasmatic Nucleus, sleep, temperature, melanopsin, ipRGC, Medicine, Science, Biology (General), QH301-705.5 |
الوصف: | The light environment greatly impacts human alertness, mood, and cognition by both acute regulation of physiology and indirect alignment of circadian rhythms. These processes require the melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs), but the relevant downstream brain areas involved remain elusive. ipRGCs project widely in the brain, including to the central circadian pacemaker, the suprachiasmatic nucleus (SCN). Here we show that body temperature and sleep responses to acute light exposure are absent after genetic ablation of all ipRGCs except a subpopulation that projects to the SCN. Furthermore, by chemogenetic activation of the ipRGCs that avoid the SCN, we show that these cells are sufficient for acute changes in body temperature. Our results challenge the idea that the SCN is a major relay for the acute effects of light on non-image forming behaviors and identify the sensory cells that initiate light’s profound effects on body temperature and sleep. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2050-084X |
Relation: | https://elifesciences.org/articles/44358; https://doaj.org/toc/2050-084X |
DOI: | 10.7554/eLife.44358 |
URL الوصول: | https://doaj.org/article/352a158e440f4e6aa38a0f92fbff5bf8 |
رقم الأكسشن: | edsdoj.352a158e440f4e6aa38a0f92fbff5bf8 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 2050084X |
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DOI: | 10.7554/eLife.44358 |