دورية أكاديمية
Anti-Inflammatory Effects of Essential Oils of Amomum aromaticum Fruits in Lipopolysaccharide-Stimulated RAW264.7 Cells
| العنوان: | Anti-Inflammatory Effects of Essential Oils of Amomum aromaticum Fruits in Lipopolysaccharide-Stimulated RAW264.7 Cells |
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| المؤلفون: | Nguyen Hai Dang, Le Thi Van Anh, Nguyen Tien Dat |
| المصدر: | Journal of Food Quality, Vol 2020 (2020) |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Nutrition. Foods and food supply |
| مصطلحات موضوعية: | Nutrition. Foods and food supply, TX341-641 |
| الوصف: | Inflammation is a vital physiologic response of cellular injury, infection, or autoimmune activation. Overproduction of proinflammatory mediators may result in the chronic inflammation that leads to many diseases such as rheumatoid arthritis, asthma, multiple sclerosis, and atherosclerosis. In this study, we assessed for the first time the anti-inflammatory effects of the essential oils of Amomum aromaticum fruits (AAE) in RAW264.7 murine macrophage model. As a result, AAE potently inhibited the production of nitric oxide in LPS-induced RAW264.7 cells with the IC50 value of 0.45 ± 0.11 μg/ml. AAE also dose-dependently reduced the expression of two proinflammatory proteins iNOS and COX-2 in the stimulated cells. Phytochemical analysis revealed that major compositions of the volatile oils including 1,8 cineole (48.22%), geranial (9.24%), neral (6.72%), α-pinene (2.43%), and α-terpineol (2.28%) may contribute greatly to the inhibition effects due to their anti-inflammatory properties. The results suggest for the potential uses of AAE in chronic inflammation prevention. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0146-9428 1745-4557 |
| Relation: | https://doaj.org/toc/0146-9428; https://doaj.org/toc/1745-4557 |
| DOI: | 10.1155/2020/8831187 |
| URL الوصول: | https://doaj.org/article/353ea55c00584bb29e5f21b8cde6000d |
| رقم الأكسشن: | edsdoj.353ea55c00584bb29e5f21b8cde6000d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 01469428 17454557 |
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| DOI: | 10.1155/2020/8831187 |