دورية أكاديمية
Is adalimumab protective in ischemia-reperfusion injury in lung?
| العنوان: | Is adalimumab protective in ischemia-reperfusion injury in lung? |
|---|---|
| المؤلفون: | Aysel Kurt, Levent Tumkaya, Yildiray Kalkan, Hasan Turut, Medine Cumhur Cure, Erkan Cure, Ibrahim Sehitoglu, Hacer Bilgin, Mustafa Usta |
| المصدر: | Iranian Journal of Basic Medical Sciences, Vol 18, Iss 11, Pp 1093-1099 (2015) |
| بيانات النشر: | Mashhad University of Medical Sciences, 2015. |
| سنة النشر: | 2015 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Adalimumab, Endothelin-1, Ischemia reperfusion, Lung injury, Tumor necrosis factor-alpha, Medicine |
| الوصف: | Objective(s): Increasing cytokines and reactive oxygen species (ROS) during ischemia reperfusion (I-R) leads to the lung damage. Adalimumab (Ada) is a potent tumor necrosis factor-alpha (TNF-α) inhibitor agent. We aimed to evaluate whether Ada would prevent the lung tissue from damage development over the I-R process. Materials and Methods:Twenty seven Wistar albino male rats were divided into three groups (each group had 9 rats). To the control group, only laparotomy procedure was carried out. For I-R group, first infrarenal abdominal aorta was cross-clamped during 2 hr, and then reperfusion was performed for 2 hr. To I-R+Ada group, first a single dose of 50 mg/kg Ada was given intraperitoneally and 5 days later, same I-R procedure was carried out. Results:Levels of TNF-α, malondialdehyde (MDA), myeloperoxidase (MPO), endothelin-1 (ET-1) and caspase-3 enzyme activity of I-R group were higher than that of both I-R+ Ada [TNF-α (P=0.021), MDA (P=0.029), MPO (P=0.012), ET-1 (P=0.036, caspase-3 (P=0.007), respectively] and control group [TNF- α (P=0.008), MDA (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2008-3866 2008-3874 |
| Relation: | http://ijbms.mums.ac.ir/pdf_6047_94fb0d10ddd4fd5c23a5fec11109ecb0.html; https://doaj.org/toc/2008-3866; https://doaj.org/toc/2008-3874 |
| URL الوصول: | https://doaj.org/article/359f5d14db4e49d2aeacc29fec694f19 |
| رقم الأكسشن: | edsdoj.359f5d14db4e49d2aeacc29fec694f19 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20083866 20083874 |
|---|