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Emerging Roles of YES1 in Cancer: The Putative Target in Drug Resistance

التفاصيل البيبلوغرافية
العنوان: Emerging Roles of YES1 in Cancer: The Putative Target in Drug Resistance
المؤلفون: Eunjin Kook, Kyung-Soo Chun, Do-Hee Kim
المصدر: International Journal of Molecular Sciences, Vol 25, Iss 3, p 1450 (2024)
بيانات النشر: MDPI AG, 2024.
سنة النشر: 2024
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: Src family kinase, YES1, drug-resistance, cancer progression, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: Src family kinases (SFKs) are non-receptor tyrosine kinases that are recognized as proto-oncogenic products. Among SFKs, YES1 is frequently amplified and overexpressed in a variety of human tumors, including lung, breast, ovarian, and skin cancers. YES1 plays a pivotal role in promoting cell proliferation, survival, and invasiveness during tumor development. Recent findings indicate that YES1 expression and activation are associated with resistance to chemotherapeutic drugs and tyrosine kinase inhibitors in human malignancies. YES1 undergoes post-translational modifications, such as lipidation and nitrosylation, which can modulate its catalytic activity, subcellular localization, and binding affinity for substrate proteins. Therefore, we investigated the diverse mechanisms governing YES1 activation and its impact on critical intracellular signal transduction pathways. We emphasized the function of YES1 as a potential mechanism contributing to the anticancer drug resistance emergence.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-0067
1661-6596
Relation: https://www.mdpi.com/1422-0067/25/3/1450; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067
DOI: 10.3390/ijms25031450
URL الوصول: https://doaj.org/article/35a3001080b44b38be11fbfe66cf4307
رقم الأكسشن: edsdoj.35a3001080b44b38be11fbfe66cf4307
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14220067
16616596
DOI:10.3390/ijms25031450