دورية أكاديمية
Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1
| العنوان: | Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1 |
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| المؤلفون: | Hye-Kyung Park, Nam Gu Yoon, Ji-Eun Lee, Sung Hu, Sora Yoon, So Yeon Kim, Jun-Hee Hong, Dougu Nam, Young Chan Chae, Jong Bae Park, Byoung Heon Kang |
| المصدر: | Experimental and Molecular Medicine, Vol 52, Iss 1, Pp 79-91 (2020) |
| بيانات النشر: | Nature Publishing Group, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine LCC:Biochemistry |
| مصطلحات موضوعية: | Medicine, Biochemistry, QD415-436 |
| الوصف: | Cancer therapeutics: Extending a drug’s reach A new drug that blocks heat shock proteins (HSPs), helper proteins that are co-opted by cancer cells to promote tumor growth, shows promise for cancer treatment. Several drugs have targeted HSPs, since cancer cells are known to hijack these helper proteins to shield themselves from destruction by the body. However, the drugs have had limited success. Hye-Kyung Park and Byoung Heon Kang at Ulsan National Institutes of Science and Technology in South Korea and coworkers noticed that the drugs were not absorbed into mitochondria, a key cellular compartment, and HSPs in this compartment were therefore not being blocked. They identified a new HSP inhibitor that can reach every cellular compartment and inhibit all HSPs. Testing in mice showed that this inhibitor effectively triggered death of tumor cells, and therefore shows promise for anti-cancer therapy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1226-3613 2092-6413 |
| Relation: | https://doaj.org/toc/1226-3613; https://doaj.org/toc/2092-6413 |
| DOI: | 10.1038/s12276-019-0360-x |
| URL الوصول: | https://doaj.org/article/35a514c7ab004b988412156186b7dc41 |
| رقم الأكسشن: | edsdoj.35a514c7ab004b988412156186b7dc41 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 12263613 20926413 |
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| DOI: | 10.1038/s12276-019-0360-x |