دورية أكاديمية
Delineation uncertainties of tumour volumes on MRI of head and neck cancer patients
| العنوان: | Delineation uncertainties of tumour volumes on MRI of head and neck cancer patients |
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| المؤلفون: | Ruta Zukauskaite, Christopher N. Rumley, Christian R. Hansen, Michael G. Jameson, Yuvnik Trada, Jørgen Johansen, Niels Gyldenkerne, Jesper G. Eriksen, Farhannah Aly, Rasmus L. Christensen, Mark Lee, Carsten Brink, Lois Holloway |
| المصدر: | Clinical and Translational Radiation Oncology, Vol 36, Iss , Pp 121-126 (2022) |
| بيانات النشر: | Elsevier, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medical physics. Medical radiology. Nuclear medicine LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Inter-observer variation, Target delineation, Head and neck cancer, MRI, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Background: During the last decade, radiotherapy using MR Linac has gone from research to clinical implementation for different cancer locations. For head and neck cancer (HNC), target delineation based only on MR images is not yet standard, and the utilisation of MRI instead of PET/CT in radiotherapy planning is not well established. We aimed to analyse the inter-observer variation (IOV) in delineating GTV (gross tumour volume) on MR images only for patients with HNC. Material/methods: 32 HNC patients from two independent departments were included. Four clinical oncologists from Denmark and four radiation oncologists from Australia had independently contoured primary tumour GTVs (GTV-T) and nodal GTVs (GTV-N) on T2-weighted MR images obtained at the time of treatment planning. Observers were provided with sets of images, delineation guidelines and patient synopsis. Simultaneous truth and performance level estimation (STAPLE) reference volumes were generated for each structure using all observer contours. The IOV was assessed using the DICE Similarity Coefficient (DSC) and mean absolute surface distance (MASD). Results: 32 GTV-Ts and 68 GTV-Ns were contoured per observer. The median MASD for GTV-Ts and GTV-Ns across all patients was 0.17 cm (range 0.08–0.39 cm) and 0.07 cm (range 0.04–0.33 cm), respectively. Median DSC relative to a STAPLE volume for GTV-Ts and GTV-Ns across all patients were 0.73 and 0.76, respectively. A significant correlation was seen between median DSCs and median volumes of GTV-Ts (Spearman correlation coefficient 0.76, p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-6308 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405630822000672; https://doaj.org/toc/2405-6308 |
| DOI: | 10.1016/j.ctro.2022.08.005 |
| URL الوصول: | https://doaj.org/article/c35a7e8bd1694803bc77a7d4282c070d |
| رقم الأكسشن: | edsdoj.35a7e8bd1694803bc77a7d4282c070d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24056308 |
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| DOI: | 10.1016/j.ctro.2022.08.005 |