دورية أكاديمية
Antioxidant and anti-inflammatory activities of Platycodon grandiflorum seeds extract
| العنوان: | Antioxidant and anti-inflammatory activities of Platycodon grandiflorum seeds extract |
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| المؤلفون: | Tae Yeong Kim, Eseo Yoon, Dabeen Lee, Jee-Young Imm |
| المصدر: | CyTA - Journal of Food, Vol 18, Iss 1, Pp 435-444 (2020) |
| بيانات النشر: | Taylor & Francis Group, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Nutrition. Foods and food supply LCC:Food processing and manufacture |
| مصطلحات موضوعية: | platycodon grandiflorum, seeds, anti-inflammation, raw 264.7 macrophage, Nutrition. Foods and food supply, TX341-641, Food processing and manufacture, TP368-456 |
| الوصف: | Antioxidant and anti-inflammatory effects of seeds and root extracts (PGSE vs. PGRE) prepared from Platycodon grandiflorum (PG) by ethanol extraction were evaluated. PGSE exhibited greater 2,2-diphenyl-l-picrylhydrazyl (DPPH•) and 2,2-azinobis (3-ethyl-benzothiazoline-6-sulfonic acid) (ABTS•+) radical scavenging activities and more effectively inhibited production of nitric oxide (NO) and prostaglandin E2 (PGE2) compare to PGRE. The release of tumor necrosis factor-α (TNF-α) was also decreased by 31% at 100 μg/mL of PGSE in LPS-stimulated RAW 264.7 macrophages. LPS-induced elevated expressions of inducible NO synthase, cyclooxygenase-2, and pro-inflammatory cytokines (interleukin (IL)-1β, IL-4, and IL-6) were significantly downregulated, in a dose-dependent manner, by PGSE treatment. The suppression of nuclear factor κB (NFκB) translocation and stimulation of heme oxygenase-1 induction were related to anti-inflammatory mechanism of PGSE. Based on these findings, PGSE has the potential to be used as a functional agent for the mitigation of inflammation related diseases. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Spanish; Castilian |
| تدمد: | 1947-6337 1947-6345 19476337 |
| Relation: | https://doaj.org/toc/1947-6337; https://doaj.org/toc/1947-6345 |
| DOI: | 10.1080/19476337.2020.1770336 |
| URL الوصول: | https://doaj.org/article/35c5fe61d61e43b08933ba667d0d039f |
| رقم الأكسشن: | edsdoj.35c5fe61d61e43b08933ba667d0d039f |
| قاعدة البيانات: | Directory of Open Access Journals |
PDF full text from Publisher 
Full Text Finder | تدمد: | 19476337 19476345 |
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| DOI: | 10.1080/19476337.2020.1770336 |