دورية أكاديمية
Protective effect of daidzein on ovarian ischemia‑reperfusion injury in rats
| العنوان: | Protective effect of daidzein on ovarian ischemia‑reperfusion injury in rats |
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| المؤلفون: | Erdem Toktay, Muhammet Ali Gürbüz, Tuğba Bal, Özlem Özgül, Elif Erbaş, Rüstem Anıl Ugan, Jale Selli |
| المصدر: | Cukurova Medical Journal, Vol 47, Iss 1, Pp 102-110 (2022) |
| بيانات النشر: | Cukurova University, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | daidzein, ovary, ischemia‑reperfusion injury, rat, ovaryum, iskemisi ve reperfüzyon hasarı, sıçan, Medicine (General), R5-920 |
| الوصف: | Purpose: In this study, our aim was to investigate the potential effects of strong antioxidant daidzein (DZ) on ovarian ischemia and reperfusion injury. Materials and Methods: A total of 42 female Sprague-Dawley rats were randomly divided into seven groups. For the experimental model, the clamps were removed after 3 hours of ischemia, and blood flow was provided again. Then, reperfusion process was terminated for 3 hours. Daidzein was orally administered to animals at doses of 35 and 70 mg/kg 30 minutes before ischemia (I) and ischemia and reperfusion (I/R) procedures. Results: Severe immunoreactivity of the IL-1β, IL-6 and Caspase-3 were detected in I and I/R groups. Moderate immunoreactivity of IL-1β, IL-6 and Caspase-3 was detected in I+DZ35 and I/R+DZ35 groups, and slightly positivity was detected in I+DZ70 and I/R+DZ70 groups. The SOD activity level increased in the groups treated with Daidzein, while MDA levels decreased. In addition, hemorrhage areas and inflammatory cell migration decreased in I/R+DZ70 and I/R+DZ35 groups, when compared to I/R group in a dose dependent manner. Conclusion: Daidzein has a strong protective role in the treatment of ovarian ischemia-reperfusion injury and can be used as a therapeutic agent. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Turkish |
| تدمد: | 2602-3040 |
| Relation: | https://dergipark.org.tr/tr/download/article-file/1965724; https://doaj.org/toc/2602-3040 |
| DOI: | 10.17826/cumj.993250 |
| URL الوصول: | https://doaj.org/article/35cd32a4128a4fa7a7e6636ff591e848 |
| رقم الأكسشن: | edsdoj.35cd32a4128a4fa7a7e6636ff591e848 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 26023040 |
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| DOI: | 10.17826/cumj.993250 |