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Bisphenol A exposure and asthma development in school-age children: a longitudinal study.

التفاصيل البيبلوغرافية
العنوان: Bisphenol A exposure and asthma development in school-age children: a longitudinal study.
المؤلفون: Kyoung-Nam Kim, Jin Hee Kim, Ho-Jang Kwon, Soo-Jong Hong, Byoung-Ju Kim, So-Yeon Lee, Yun-Chul Hong, Sanghyuk Bae
المصدر: PLoS ONE, Vol 9, Iss 10, p e111383 (2014)
بيانات النشر: Public Library of Science (PLoS), 2014.
سنة النشر: 2014
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: BACKGROUND:Although the effect of bisphenol A on various health outcomes has been extensively examined, few studies have investigated its effect on asthma. OBJECTIVE:We hypothesized that exposure to bisphenol A in school-age children was associated with wheezing and asthma. METHODS:Participants included 127 children aged 7-8 years without a previous asthma diagnosis in an elementary school in Seoul, Korea. Three surveys were conducted, each 2 years apart. Bisphenol A concentration was measured at the baseline survey, and PC20, which is defined as the methacholine concentration that induces a decrease in FEV1 of 20% from baseline, was measured at every survey. Associations between bisphenol A concentration at 7-8 years of age and wheezing, asthma, and PC20 at ages up to 11-12 years were examined using generalized estimating equations, a marginal Cox regression model, and a linear mixed model. RESULTS:The log-transformed creatinine-adjusted urinary bisphenol A concentration at 7-8 years was positively associated with wheezing (odds ratio, 2.48; 95% confidence interval, 1.15-5.31; P = .02) and asthma (hazard ratio, 2.13; 95% confidence interval, 1.51-3.00; P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC4214730?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0111383
URL الوصول: https://doaj.org/article/35db0014b139481a9f8cf3f8720336a2
رقم الأكسشن: edsdoj.35db0014b139481a9f8cf3f8720336a2
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0111383