دورية أكاديمية
أعرض في EDS

Circular RNA GLI2 promotes osteosarcoma cell proliferation, migration, and invasion by targeting miR-125b-5p

التفاصيل البيبلوغرافية
العنوان: Circular RNA GLI2 promotes osteosarcoma cell proliferation, migration, and invasion by targeting miR-125b-5p
المؤلفون: Ji-Feng Li, Yu-Ze Song
المصدر: Tumor Biology, Vol 39 (2017)
بيانات النشر: IOS Press, 2017.
سنة النشر: 2017
المجموعة: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Circular RNAs are novel identified type of endogenous non-coding RNAs, which exert vital functions in human and animals. However, the in-depth role of circular RNAs in the progression of tumorigenesis, especially osteosarcoma, is still undefined. Our preliminary study had found that cir-GLI2 was significantly upregulated in osteosarcoma tissues compared to adjacent non-tumor tissue. Moreover, cir-GLI2 silencing could effectively suppress the proliferation, migration, and invasion capacity of osteosarcoma cells, indicating the tumor-promoting role. Besides, bioinformatics analysis and luciferase reporter assay predicted the direct binding to miR-125b-5p, which has been reported to function as a tumor suppressor in osteosarcoma. Furthermore, functional experiments validated that cir-GLI2 exerted the tumor-promoting effects on osteosarcoma cells via negatively targeting miR-125b-5p. In conclusion, our study demonstrated that cir-GLI2 acts as an oncogenic circular RNA in osteosarcoma genesis, providing a novel diagnostic and therapeutic target for osteosarcoma.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1423-0380
10104283
Relation: https://doaj.org/toc/1423-0380
DOI: 10.1177/1010428317709991
URL الوصول: https://doaj.org/article/360eeae3159e45859c81cda099cdce93
رقم الأكسشن: edsdoj.360eeae3159e45859c81cda099cdce93
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14230380
10104283
DOI:10.1177/1010428317709991