دورية أكاديمية
Circular RNA GLI2 promotes osteosarcoma cell proliferation, migration, and invasion by targeting miR-125b-5p
العنوان: | Circular RNA GLI2 promotes osteosarcoma cell proliferation, migration, and invasion by targeting miR-125b-5p |
---|---|
المؤلفون: | Ji-Feng Li, Yu-Ze Song |
المصدر: | Tumor Biology, Vol 39 (2017) |
بيانات النشر: | IOS Press, 2017. |
سنة النشر: | 2017 |
المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
مصطلحات موضوعية: | Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
الوصف: | Circular RNAs are novel identified type of endogenous non-coding RNAs, which exert vital functions in human and animals. However, the in-depth role of circular RNAs in the progression of tumorigenesis, especially osteosarcoma, is still undefined. Our preliminary study had found that cir-GLI2 was significantly upregulated in osteosarcoma tissues compared to adjacent non-tumor tissue. Moreover, cir-GLI2 silencing could effectively suppress the proliferation, migration, and invasion capacity of osteosarcoma cells, indicating the tumor-promoting role. Besides, bioinformatics analysis and luciferase reporter assay predicted the direct binding to miR-125b-5p, which has been reported to function as a tumor suppressor in osteosarcoma. Furthermore, functional experiments validated that cir-GLI2 exerted the tumor-promoting effects on osteosarcoma cells via negatively targeting miR-125b-5p. In conclusion, our study demonstrated that cir-GLI2 acts as an oncogenic circular RNA in osteosarcoma genesis, providing a novel diagnostic and therapeutic target for osteosarcoma. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1423-0380 10104283 |
Relation: | https://doaj.org/toc/1423-0380 |
DOI: | 10.1177/1010428317709991 |
URL الوصول: | https://doaj.org/article/360eeae3159e45859c81cda099cdce93 |
رقم الأكسشن: | edsdoj.360eeae3159e45859c81cda099cdce93 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 14230380 10104283 |
---|---|
DOI: | 10.1177/1010428317709991 |