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MicroRNA and metabolomics signatures for adrenomyeloneuropathy disease severity

التفاصيل البيبلوغرافية
العنوان: MicroRNA and metabolomics signatures for adrenomyeloneuropathy disease severity
المؤلفون: Bela Rui Turk, Laila Marie Poisson, Christina Linnea Nemeth, Jordan Goodman, Ann B. Moser, Richard Owen Jones, Ali Fatemi, Jaspreet Singh
المصدر: JIMD Reports, Vol 63, Iss 6, Pp 593-603 (2022)
بيانات النشر: Wiley, 2022.
سنة النشر: 2022
المجموعة: LCC:Diseases of the endocrine glands. Clinical endocrinology
LCC:Genetics
مصطلحات موضوعية: adrenoleukodystrophy, adrenomyeloneuropathy, biomarker, leukodystrophy, metabolomics, micro‐RNA, Diseases of the endocrine glands. Clinical endocrinology, RC648-665, Genetics, QH426-470
الوصف: Abstract Adrenomyeloneuropathy (AMN), the slow progressive phenotype of adrenoleukodystrophy (ALD), has no clinical plasma biomarker for disease progression. This feasibility study aimed to determine whether metabolomics and micro‐RNA in blood plasma provide a potential source of biomarkers for AMN disease severity. Metabolomics and RNA‐seq were performed on AMN and healthy human blood plasma. Biomarker discovery and pathway analyses were performed using clustering, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, and regression against patient's clinical Expanded Disability Status Score (EDSS). Fourteen AMN and six healthy control samples were analyzed. AMN showed strong disease‐severity‐specific metabolic and miRNA clustering signatures. Strong, significant clinical correlations were shown for 7‐alpha‐hydroxy‐3‐oxo‐4‐cholestenoate (7‐HOCA) (r2 = 0.83, p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2192-8312
Relation: https://doaj.org/toc/2192-8312
DOI: 10.1002/jmd2.12323
URL الوصول: https://doaj.org/article/36123677d2714446a40c64bbf255f8ce
رقم الأكسشن: edsdoj.36123677d2714446a40c64bbf255f8ce
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:21928312
DOI:10.1002/jmd2.12323