دورية أكاديمية
MicroRNA and metabolomics signatures for adrenomyeloneuropathy disease severity
العنوان: | MicroRNA and metabolomics signatures for adrenomyeloneuropathy disease severity |
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المؤلفون: | Bela Rui Turk, Laila Marie Poisson, Christina Linnea Nemeth, Jordan Goodman, Ann B. Moser, Richard Owen Jones, Ali Fatemi, Jaspreet Singh |
المصدر: | JIMD Reports, Vol 63, Iss 6, Pp 593-603 (2022) |
بيانات النشر: | Wiley, 2022. |
سنة النشر: | 2022 |
المجموعة: | LCC:Diseases of the endocrine glands. Clinical endocrinology LCC:Genetics |
مصطلحات موضوعية: | adrenoleukodystrophy, adrenomyeloneuropathy, biomarker, leukodystrophy, metabolomics, micro‐RNA, Diseases of the endocrine glands. Clinical endocrinology, RC648-665, Genetics, QH426-470 |
الوصف: | Abstract Adrenomyeloneuropathy (AMN), the slow progressive phenotype of adrenoleukodystrophy (ALD), has no clinical plasma biomarker for disease progression. This feasibility study aimed to determine whether metabolomics and micro‐RNA in blood plasma provide a potential source of biomarkers for AMN disease severity. Metabolomics and RNA‐seq were performed on AMN and healthy human blood plasma. Biomarker discovery and pathway analyses were performed using clustering, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, and regression against patient's clinical Expanded Disability Status Score (EDSS). Fourteen AMN and six healthy control samples were analyzed. AMN showed strong disease‐severity‐specific metabolic and miRNA clustering signatures. Strong, significant clinical correlations were shown for 7‐alpha‐hydroxy‐3‐oxo‐4‐cholestenoate (7‐HOCA) (r2 = 0.83, p |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2192-8312 |
Relation: | https://doaj.org/toc/2192-8312 |
DOI: | 10.1002/jmd2.12323 |
URL الوصول: | https://doaj.org/article/36123677d2714446a40c64bbf255f8ce |
رقم الأكسشن: | edsdoj.36123677d2714446a40c64bbf255f8ce |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 21928312 |
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DOI: | 10.1002/jmd2.12323 |