دورية أكاديمية
Antinociceptive modulation by the adhesion GPCR CIRL promotes mechanosensory signal discrimination
| العنوان: | Antinociceptive modulation by the adhesion GPCR CIRL promotes mechanosensory signal discrimination |
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| المؤلفون: | Sven Dannhäuser, Thomas J Lux, Chun Hu, Mareike Selcho, Jeremy T-C Chen, Nadine Ehmann, Divya Sachidanandan, Sarah Stopp, Dennis Pauls, Matthias Pawlak, Tobias Langenhan, Peter Soba, Heike L Rittner, Robert J Kittel |
| المصدر: | eLife, Vol 9 (2020) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | adhesion-GPCR, mechanosensory physiology, nociception, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | Adhesion-type GPCRs (aGPCRs) participate in a vast range of physiological processes. Their frequent association with mechanosensitive functions suggests that processing of mechanical stimuli may be a common feature of this receptor family. Previously, we reported that the Drosophila aGPCR CIRL sensitizes sensory responses to gentle touch and sound by amplifying signal transduction in low-threshold mechanoreceptors (Scholz et al., 2017). Here, we show that Cirl is also expressed in high-threshold mechanical nociceptors where it adjusts nocifensive behaviour under physiological and pathological conditions. Optogenetic in vivo experiments indicate that CIRL lowers cAMP levels in both mechanosensory submodalities. However, contrasting its role in touch-sensitive neurons, CIRL dampens the response of nociceptors to mechanical stimulation. Consistent with this finding, rat nociceptors display decreased Cirl1 expression during allodynia. Thus, cAMP-downregulation by CIRL exerts opposing effects on low-threshold mechanosensors and high-threshold nociceptors. This intriguing bipolar action facilitates the separation of mechanosensory signals carrying different physiological information. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| Relation: | https://elifesciences.org/articles/56738; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.56738 |
| URL الوصول: | https://doaj.org/article/3621e5484bc74582b2f575daf6b07b1f |
| رقم الأكسشن: | edsdoj.3621e5484bc74582b2f575daf6b07b1f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.56738 |