دورية أكاديمية
Effects of Enzymatic Hydrolysis on the Allergenicity of Whey Protein Concentrates
| العنوان: | Effects of Enzymatic Hydrolysis on the Allergenicity of Whey Protein Concentrates |
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| المؤلفون: | Cuicui Duan, Lijie Yang, Aili Li, Rui Zhao, Gui-Cheng Huo |
| المصدر: | Iranian Journal of Allergy, Asthma and Immunology, Vol 13, Iss 4 (2014) |
| بيانات النشر: | Tehran University of Medical Sciences, 2014. |
| سنة النشر: | 2014 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Hydrolysis, Hypersensitivity, Mouse, Whey protein, Medicine |
| الوصف: | Cow’s milk whey consists of many protein components and some of them are antigens to human and known to modulate immune responses. Enzymatic hydrolysis is a useful method to modify proteins with allergenicity. The objective of this study was to identify whether the in vitro enzymatic hydrolysis could reduce the allergenicity of whey protein concentrates (WPC). In this study, WPC were hydrolyzed by trypsin and twenty-four BALB/c mice were divided into three groups and fed with WPC formula and WPC hydrolysates formula, while the control mice received milk-free diet. The results revealed that there was no significant difference between the body weights among all groups. WPC-fed mice produced an elevated spleen lymphocyte proliferation level than WPC hydrolysates-fed mice and also produced higher levels of WPC-specific IgE in intestinal tract and serum in comparison to WPC hydrolysates-fed mice and control group. Significant up-regulation of plasma histamine levels were also observed and showed the same trend with IgE. The secretions of IL-4 and IL-5 were significantly enhanced by WPC. WPC significantly suppressed the secretion of IFN-γ while hydrolysates of WPC significantly increased the secretion of IFN-γ compared to control group. These results suggest that hydrolysis may play a role to reduce the allergenicity of WPC. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1735-1502 1735-5249 |
| Relation: | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/451; https://doaj.org/toc/1735-1502; https://doaj.org/toc/1735-5249 |
| URL الوصول: | https://doaj.org/article/e362f23b9e6040538b02bc70ae54e986 |
| رقم الأكسشن: | edsdoj.362f23b9e6040538b02bc70ae54e986 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17351502 17355249 |
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