دورية أكاديمية
Type-I-interferons in infection and cancer: Unanticipated dynamics with therapeutic implications
| العنوان: | Type-I-interferons in infection and cancer: Unanticipated dynamics with therapeutic implications |
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| المؤلفون: | Martina Musella, Gwenola Manic, Ruggero De Maria, Ilio Vitale, Antonella Sistigu |
| المصدر: | OncoImmunology, Vol 6, Iss 5 (2017) |
| بيانات النشر: | Taylor & Francis Group, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Immunologic diseases. Allergy LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | anticancer therapy, cancer stem cells, ifns, immunotherapy, tumor immunity, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | If there is a great new hope in the treatment of cancer, the immune system is it. Innate and adaptive immunity either promote or attenuate tumorigenesis and so can have opposing effects on the therapeutic outcome. Originally described as potent antivirals, Type-I interferons (IFNs) were quickly recognized as central coordinators of tumor-immune system interactions. Type-I-IFNs are produced by, and act on, both tumor and immune cells being either host-protecting or tumor-promoting. Here, we discuss Type-I-IFNs in infectious and cancer diseases highlighting their dichotomous role and raising the importance to deeply understand the underlying mechanisms so to reshape the way we can exploit Type-I-IFNs therapeutically. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2162-402X 2162402X |
| Relation: | https://doaj.org/toc/2162-402X |
| DOI: | 10.1080/2162402X.2017.1314424 |
| URL الوصول: | https://doaj.org/article/366ebe8c600e4651a324b9e83793f59f |
| رقم الأكسشن: | edsdoj.366ebe8c600e4651a324b9e83793f59f |
| قاعدة البيانات: | Directory of Open Access Journals |
PDF full text from Publisher | تدمد: | 2162402X |
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| DOI: | 10.1080/2162402X.2017.1314424 |