دورية أكاديمية
The Effects of Physiological and Methodological Determinants on F-FDG Mouse Brain Imaging Exemplified in a Double Transgenic Alzheimer Model
| العنوان: | The Effects of Physiological and Methodological Determinants on F-FDG Mouse Brain Imaging Exemplified in a Double Transgenic Alzheimer Model |
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| المؤلفون: | Steven Deleye MSc, Ann-Marie Waldron MSc, Jill C. Richardson PhD, Mark Schmidt PhD, Xavier Langlois PhD, Sigrid Stroobants MD, PhD, Steven Staelens PhD |
| المصدر: | Molecular Imaging, Vol 15 (2016) |
| بيانات النشر: | SAGE Publications, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | LCC:Biology (General) LCC:Medical technology |
| مصطلحات موضوعية: | Biology (General), QH301-705.5, Medical technology, R855-855.5 |
| الوصف: | Introduction: In this study, the influence of physiological determinants on 18F-fluoro- d -glucose ( 18 F-FDG) brain uptake was evaluated in a mouse model of Alzheimer disease. Materials and Methods: TASTPM (Tg) and age-matched C57BL/6 J (WT) mice were fasted for 10 hours, while another group was fasted for 20 hours to evaluate the effect of fasting duration. The effect of repeatedly scanning was evaluated by scanning Tg and WT mice at days 1, 4, and 7. Brain 18 F-FDG uptake was evaluated in the thalamus being the most indicative region. Finally, the cerebellum was tested as a reference region for the relative standard uptake value (rSUV). Results: When correcting the brain uptake for glucose, the effect of different fasting durations was attenuated and the anticipated hypometabolism in Tg mice was demonstrated. Also, with repeated scanning, the brain uptake values within a group and the hypometabolism of the Tg mice only remained stable over time when glucose correction was applied. Finally, hypometabolism was also observed in the cerebellum, yielding artificially higher rSUV values for Tg mice. Conclusion: Corrections for blood glucose levels have to be applied when semiquantifying 18 F-FDG brain uptake in mouse models for AD. Potential reference regions for normalization should be thoroughly investigated to ensure that they are not pathologically affected also by afferent connections. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1536-0121 15360121 |
| Relation: | https://doaj.org/toc/1536-0121 |
| DOI: | 10.1177/1536012115624919 |
| URL الوصول: | https://doaj.org/article/a367047fc0644842a2d1c1a2ee15907f |
| رقم الأكسشن: | edsdoj.367047fc0644842a2d1c1a2ee15907f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15360121 |
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| DOI: | 10.1177/1536012115624919 |