دورية أكاديمية

Bright Green Biofluorescence in Sharks Derives from Bromo-Kynurenine Metabolism

التفاصيل البيبلوغرافية
العنوان: Bright Green Biofluorescence in Sharks Derives from Bromo-Kynurenine Metabolism
المؤلفون: Hyun Bong Park, Yick Chong Lam, Jean P. Gaffney, James C. Weaver, Sara Rose Krivoshik, Randy Hamchand, Vincent Pieribone, David F. Gruber, Jason M. Crawford
المصدر: iScience, Vol 19, Iss , Pp 1291-1336 (2019)
بيانات النشر: Elsevier, 2019.
سنة النشر: 2019
المجموعة: LCC:Science
مصطلحات موضوعية: Science
الوصف: Summary: Although in recent years there has been an increased awareness of the widespread nature of biofluorescence in the marine environment, the diversity of the molecules responsible for this luminescent phenotype has been mostly limited to green fluorescent proteins (GFPs), GFP-like proteins, and fluorescent fatty acid-binding proteins (FABPs). In the present study, we describe a previously undescribed group of brominated tryptophan-kynurenine small molecule metabolites responsible for the green biofluorescence in two species of sharks and provide their structural, antimicrobial, and spectral characterization. Multi-scale fluorescence microscopy studies guided the discovery of metabolites that were differentially produced in fluorescent versus non-fluorescent skin, as well as the species-specific structural details of their unusual light-guiding denticles. Overall, this study provides the detailed description of a family of small molecules responsible for marine biofluorescence and opens new questions related to their roles in central nervous system signaling, resilience to microbial infections, and photoprotection. : Chemistry; Natural Product Chemistry; Natural Product Discovery Subject Areas: Chemistry, Natural Product Chemistry, Natural Product Discovery
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2589-0042
Relation: http://www.sciencedirect.com/science/article/pii/S2589004219302445; https://doaj.org/toc/2589-0042
DOI: 10.1016/j.isci.2019.07.019
URL الوصول: https://doaj.org/article/368e72aaf4b24ba0af0052c8876715dc
رقم الأكسشن: edsdoj.368e72aaf4b24ba0af0052c8876715dc
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:25890042
DOI:10.1016/j.isci.2019.07.019