دورية أكاديمية
Important problems in the diagnosis and treatment of primary sclerosing cholangitis (based on the Russian consensus on diagnosis and treatment autoimmune hepatitis. Moscow, 2018)
| العنوان: | Important problems in the diagnosis and treatment of primary sclerosing cholangitis (based on the Russian consensus on diagnosis and treatment autoimmune hepatitis. Moscow, 2018) |
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| المؤلفون: | E V Vinnitskaya, S R Abdulkhakov, D T Abdurakhmanov, R B Alikhanov, I G Bakulin, E A Belousova, A O Bueverov, E Z Burnevitch, M G Efanov, E Yu Eremina, T M Ignatova, L Yu Ilchenko, G G Karmazanovsky, O V Knyazev, Yu V Kulezneva, T N Lopatkina, T P Nekrasova, I G Nikitin, V V Pavlenko, A I Parfenov, S D Podymova, K L Raichelson, A R Reisis, R G Sayfutdinov, E V Skazyvaeva, V E Syutkin, S G Khomeriki, T Yu Haimenova, Yu G Sandler |
| المصدر: | Терапевтический архив, Vol 91, Iss 2, Pp 9-15 (2019) |
| بيانات النشر: | "Consilium Medicum" Publishing house, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | primary sclerosing cholangitis, phenotypes, liver biopsy, magnetic resonance cholangiography, ursodeoxycholic acid, Medicine |
| الوصف: | The article is published based on the results of the Russian Consensus on the diagnosis and treatment of primary sclerosing cholangitis (PSC), discussed at the 44th annual Scientific Session of the CNIIG "Personalized Medicine in the Era of Standards" (March 1, 2018). The aim of the review is to highlight the current issues of classification of diagnosis and treatment of patients with PSC, which causes the greatest interest of specialists. The urgency of the problem is determined by the multivariate nature of the clinical manifestations, by often asymptomatic flow, severe prognosis, complexity of diagnosis and insufficient study of PSC, the natural course of which in some cases can be considered as a function with many variables in terms of the nature and speed of progression with numerous possible clinical outcomes. In addition to progression to portal hypertension, cirrhosis and its complications, PSC can be accompanied by clinical manifestations of obstructive jaundice, bacterial cholangitis, cholangiocarcinoma and colorectal cancer. Magnetic resonance cholangiography is the main method of radial diagnostics of PSC, which allows to obtain an image of bile ducts in an un-invasive way. The use of liver biopsy is best justified when there is a suspicion of small-diameter PSC, autoimmune cross-syndrome PSC-AIG, IgG4-sclerosing cholangitis. Currently, a drug registered to treat primary sclerosing cholangitis which can significantly change the course and prognosis of the disease does not exist. There is no unified view on the effectiveness and usefulness of ursodeoxycholic acid and its dosage in PSC. Early diagnosis and determination of the phenotype of PSC is of clinical importance. It allows to determine the tactics of treatment, detection and prevention of complications |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Russian |
| تدمد: | 0040-3660 2309-5342 00403660 |
| Relation: | https://ter-arkhiv.ru/0040-3660/article/viewFile/32896/pdf; https://doaj.org/toc/0040-3660; https://doaj.org/toc/2309-5342 |
| DOI: | 10.26442/00403660.2019.02.000075 |
| URL الوصول: | https://doaj.org/article/369fbd970a524d809c932e64bb20426a |
| رقم الأكسشن: | edsdoj.369fbd970a524d809c932e64bb20426a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 00403660 23095342 |
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| DOI: | 10.26442/00403660.2019.02.000075 |