دورية أكاديمية
HOXB8 enhances the proliferation and metastasis of colorectal cancer cells by promoting EMT via STAT3 activation
| العنوان: | HOXB8 enhances the proliferation and metastasis of colorectal cancer cells by promoting EMT via STAT3 activation |
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| المؤلفون: | Tingting Wang, Feiyan Lin, Xuecheng Sun, Lei Jiang, Ruibo Mao, Shenyue Zhou, Wenjing Shang, Ruichun Bi, Fengying Lu, Shaotang Li |
| المصدر: | Cancer Cell International, Vol 19, Iss 1, Pp 1-12 (2019) |
| بيانات النشر: | BMC, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens LCC:Cytology |
| مصطلحات موضوعية: | Colorectal cancer, Epithelial–mesenchymal transition, HOXB8, Signal transducer and activator of transcription 3, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671 |
| الوصف: | Abstract Background Previous studies have demonstrated that the expression of homeobox8 (HOXB8) is higher in colorectal cancer (CRC) tissues than in normal tissues; however, the precise role of HOXB8 in human CRC cells remains to be elucidated. Methods We generated lentiviral constructs to overexpress and silence HOXB8 in CRC cell lines, and examined their biological functions through MTT, wound healing, colony and transwell, expression of signal transducer and activator of transcription 3 (STAT3) and epithelial–mesenchymal transition (EMT) related factors through western-blot. Results HOXB8 knockdown inhibited cellular proliferation and invasion in vitro as well as carcinogenesis and metastasis in vivo. HOXB8 also induced EMT, which is characterized by the down-regulation of E-cadherin and the up-regulation of Vimentin, N-cadherin, Twist, Zeb1 and Zeb2. Moreover, HOXB8 activated STAT3, which is known to play an oncogenic role in diverse human malignancies. Conclusions Our results indicate that HOXB8 may be an independent prognostic factor in CRC. Therefore, deserved a deeper research. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1475-2867 |
| Relation: | http://link.springer.com/article/10.1186/s12935-018-0717-6; https://doaj.org/toc/1475-2867 |
| DOI: | 10.1186/s12935-018-0717-6 |
| URL الوصول: | https://doaj.org/article/d36bc41644904d199afa9b0b7e682a29 |
| رقم الأكسشن: | edsdoj.36bc41644904d199afa9b0b7e682a29 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 14752867 |
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| DOI: | 10.1186/s12935-018-0717-6 |