دورية أكاديمية
Urine Proteomics Revealed a Significant Correlation Between Urine-Fibronectin Abundance and Estimated-GFR Decline in Patients with Bardet-Biedl Syndrome
| العنوان: | Urine Proteomics Revealed a Significant Correlation Between Urine-Fibronectin Abundance and Estimated-GFR Decline in Patients with Bardet-Biedl Syndrome |
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| المؤلفون: | Marianna Caterino, Miriam Zacchia, Michele Costanzo, Giuliana Bruno, Davide Arcaniolo, Francesco Trepiccione, Rosa Anna Siciliano, Maria Fiorella Mazzeo, Margherita Ruoppolo, Giovambattista Capasso |
| المصدر: | Kidney & Blood Pressure Research, Vol 43, Iss 2, Pp 389-405 (2018) |
| بيانات النشر: | Karger Publishers, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Dermatology LCC:Diseases of the circulatory (Cardiovascular) system LCC:Diseases of the genitourinary system. Urology |
| مصطلحات موضوعية: | Bardet-Biedl Syndrome, Kidney dysfunction, Urine proteome, Fibronectin, GFR decline, Dermatology, RL1-803, Diseases of the circulatory (Cardiovascular) system, RC666-701, Diseases of the genitourinary system. Urology, RC870-923 |
| الوصف: | Background:/Aims: Renal disease is a common cause of morbidity in patients with Bardet-Biedl syndrome (BBS), however the severity of kidney dysfunction is highly variable. To date, there is little information on the pathogenesis, the risk and predictor factors for poor renal outcome in this setting. The present study aims to analyze the spectrum of urinary proteins in BBS patients, in order to potentially identify 1) disease-specific proteomic profiles that may differentiate the patients from normal subjects; 2) urinary markers of renal dysfunction. Methods: Fourteen individuals (7 males and 7 females) with a clinical diagnosis of BBS have been selected in this study. A pool of 10 aged-matched males and 10 aged-matched females have been used as controls for proteomic analysis. The glomerular filtration rate (eGFR) has been estimated using the CKD-EPI formula. Variability of eGFR has been retrospectively assessed calculating average annual eGFR decline (ΔeGFR) in a mean follow-up period of 4 years (3-7). Results: 42 proteins were significantly over- or under-represented in BBS patients compared with controls; the majority of these proteins are involved in fibrosis, cell adhesion and extracellular matrix organization. Statistic studies revealed a significant correlation between urine fibronectin (u-FN) (r2=0.28; p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1420-4096 1423-0143 |
| Relation: | https://www.karger.com/Article/FullText/488096; https://doaj.org/toc/1420-4096; https://doaj.org/toc/1423-0143 |
| DOI: | 10.1159/000488096 |
| URL الوصول: | https://doaj.org/article/e36cfeeffeb14c3085cf6d6335dfa802 |
| رقم الأكسشن: | edsdoj.36cfeeffeb14c3085cf6d6335dfa802 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14204096 14230143 |
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| DOI: | 10.1159/000488096 |