دورية أكاديمية
Interactive effect of 6 weeks of High-intensity interval training and quercetin supplementation on expression of some tumor angiogenesis markers in female mice with breast cancer
| العنوان: | Interactive effect of 6 weeks of High-intensity interval training and quercetin supplementation on expression of some tumor angiogenesis markers in female mice with breast cancer |
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| المؤلفون: | Zohreh Jalali, Fereshteh Shahidi, abbas ali Gaeini, Shaban Alizadeh, Alireza Ramezani |
| المصدر: | مجله پزشکی دانشگاه علوم پزشکی تبریز, Vol 43, Iss 1, Pp 142-151 (2021) |
| بيانات النشر: | Tabriz University of Medical Sciences, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | breast cancer, vascular endothelial growth factor, quercetin, tie-2 receptor, Medicine |
| الوصف: | Background: About angiogenesis, metastasis of breast cancer and exercise, Many studies have been done in recent decades to better understand of regulatory mechanisms. The purpose of this study was to investigate the Interactive effect of high-intensity interval training (HIIT) and quercetin supplementation (Q) on the expression of key angiogenic factors in tumor tissue of mouse with breast cancer. Methods: Twenty-four female Balb/C mouse were injected with estrogen receptor-dependent breast cancer cells MC4L2 and then divided into three groups of tumor (T), tumor + of high-intensity interval training (TH) and tumor + high-intensity interval training + quercetin (THQ). The TH and THQ groups ran the treadmill 3 days a week for 6 weeks and each session 1 hour. The THQ group received 110 mg / kg quercetin solution for 6 weeks, 3 days a week with training. After completion of the work, the mouse were sacrificed and their tumor tissue removed and frozen in liquid nitrogen And stored at -70 ° C. Expression of TIE-2 and VEGF-A genes was measured by REAL TIME-PCR. ΔCt, ΔΔCt, and Fold change were calculated with the relevant statistical tests at the significant level (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Persian |
| تدمد: | 2783-2031 2783-204X |
| Relation: | https://mj.tbzmed.ac.ir/PDF/mj-43-1-142.pdf; https://doaj.org/toc/2783-2031; https://doaj.org/toc/2783-204X |
| DOI: | 10.34172/mj.2021.039 |
| URL الوصول: | https://doaj.org/article/36fdd99f31024ca0acfc5231a38aa3b6 |
| رقم الأكسشن: | edsdoj.36fdd99f31024ca0acfc5231a38aa3b6 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 27832031 2783204X |
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| DOI: | 10.34172/mj.2021.039 |