دورية أكاديمية
Oxytocin-induced anxiogenic behavior in juvenile male rats
| العنوان: | Oxytocin-induced anxiogenic behavior in juvenile male rats |
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| المؤلفون: | Minji Jang, Taesub Jung, Miseon Kang, Jeongyeon Kim, Jihyun Noh |
| المصدر: | Animal Cells and Systems, Vol 25, Iss 6, Pp 369-376 (2021) |
| بيانات النشر: | Taylor & Francis Group, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | anxiety, emotional behavior, nicotine aversion, oxytocin, stress, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | Oxytocin (OT) is considered beneficial to mental health owing to its anxiolytic, prosocial, and anti-stress effects; however, the adverse effects of OT have been controversial, such as its potentially anxiogenic actions. Although OT influences drug abuse and reciprocally affects vulnerability to drug use, the relationship between OT’s anxiogenic working and nicotine preference intake has not been clearly defined. To clarify this issue, the effect of acute peripheral administration of OT on anxiety and nicotine preference was investigated in juvenile male rats. Anxiogenic behaviors were noticeably increased in OT-administrated rats, with an increase in serum corticosterone levels. Moreover, increased anxiety-like behaviors and corticosterone levels were observed in the OT analog carbetocin-injected rats. In the nicotine preference test, the rats’ aversive responses to initial nicotine choice and preference were not significantly different between saline-injected and OT-injected rats. However, when administered with OT, there was a significant negative correlation between anxiety-like behavior and low-dose nicotine consumption. Collectively, these results provide evidence that acute OT exposure could induce anxiogenic behavior with corticosterone augmentation, contributing to the attenuation of nicotine preference. This suggests that both aspects of OT, as well as their benefits and drawbacks, should be considered. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1976-8354 2151-2485 19768354 |
| Relation: | https://doaj.org/toc/1976-8354; https://doaj.org/toc/2151-2485 |
| DOI: | 10.1080/19768354.2021.1995485 |
| URL الوصول: | https://doaj.org/article/370a30774e254934b7b4906f7dce6e5c |
| رقم الأكسشن: | edsdoj.370a30774e254934b7b4906f7dce6e5c |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 19768354 21512485 |
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| DOI: | 10.1080/19768354.2021.1995485 |