دورية أكاديمية
Inhibition potential of phenolic constituents from the aerial parts of Tetrastigma hemsleyanum against soluble epoxide hydrolase and nitric oxide synthase
| العنوان: | Inhibition potential of phenolic constituents from the aerial parts of Tetrastigma hemsleyanum against soluble epoxide hydrolase and nitric oxide synthase |
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| المؤلفون: | Cai Yi Wang, Sunggun Lee, Hyun-Jae Jang, Xiang Dong Su, Heng-Shan Wang, Young Ho Kim, Seo Young Yang |
| المصدر: | Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 753-760 (2019) |
| بيانات النشر: | Taylor & Francis Group, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | tetrastigma hemsleyanum, vitaceae, phenolics, soluble epoxide hydrolase, nitric oxide synthase, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | The aerial parts of Tetrastigma hemsleyanum (APTH) have been used as a functional tea in China. The purpose of the current study was to identify the bioactive constituents with inhibitory activity against soluble epoxide hydrolase (sEH) and inducible nitric oxide synthase (iNOS), which are jointly considered potential therapeutic targets for vascular system diseases. In the present study, 39 compounds (1–39) were isolated from the APTH. Among them, compounds 8, 10, 12, 16, 17, 19, and 32 displayed potential activities, with IC50 values ranging from 4.5 to 9.5 µM, respectively, and all in non-competitive inhibition mode. Compounds 5, 10, 12, 19, and 32 displayed potent iNOS inhibitory effects, with IC50 values ranging from 15.6 to 47.3 µM. The results obtained in this work contribute to a better understanding of the pharmacological activities of T. hemsleyanum and its potential application as a functional food. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1475-6366 1475-6374 14756366 |
| Relation: | https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374 |
| DOI: | 10.1080/14756366.2019.1584621 |
| URL الوصول: | https://doaj.org/article/371454eb299f4b12866c243dd36d3bb4 |
| رقم الأكسشن: | edsdoj.371454eb299f4b12866c243dd36d3bb4 |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 14756366 14756374 |
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| DOI: | 10.1080/14756366.2019.1584621 |