دورية أكاديمية
Microstructural and neurochemical plasticity mechanisms interact to enhance human perceptual decision-making.
العنوان: | Microstructural and neurochemical plasticity mechanisms interact to enhance human perceptual decision-making. |
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المؤلفون: | Joseph J Ziminski, Polytimi Frangou, Vasilis M Karlaftis, Uzay Emir, Zoe Kourtzi |
المصدر: | PLoS Biology, Vol 21, Iss 3, p e3002029 (2023) |
بيانات النشر: | Public Library of Science (PLoS), 2023. |
سنة النشر: | 2023 |
المجموعة: | LCC:Biology (General) |
مصطلحات موضوعية: | Biology (General), QH301-705.5 |
الوصف: | Experience and training are known to boost our skills and mold the brain's organization and function. Yet, structural plasticity and functional neurotransmission are typically studied at different scales (large-scale networks, local circuits), limiting our understanding of the adaptive interactions that support learning of complex cognitive skills in the adult brain. Here, we employ multimodal brain imaging to investigate the link between microstructural (myelination) and neurochemical (GABAergic) plasticity for decision-making. We test (in males, due to potential confounding menstrual cycle effects on GABA measurements in females) for changes in MRI-measured myelin, GABA, and functional connectivity before versus after training on a perceptual decision task that involves identifying targets in clutter. We demonstrate that training alters subcortical (pulvinar, hippocampus) myelination and its functional connectivity to visual cortex and relates to decreased visual cortex GABAergic inhibition. Modeling interactions between MRI measures of myelin, GABA, and functional connectivity indicates that pulvinar myelin plasticity interacts-through thalamocortical connectivity-with GABAergic inhibition in visual cortex to support learning. Our findings propose a dynamic interplay of adaptive microstructural and neurochemical plasticity in subcortico-cortical circuits that supports learning for optimized decision-making in the adult human brain. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1544-9173 1545-7885 |
Relation: | https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885 |
DOI: | 10.1371/journal.pbio.3002029 |
URL الوصول: | https://doaj.org/article/37195b02fc1b46ac87f0096227356df0 |
رقم الأكسشن: | edsdoj.37195b02fc1b46ac87f0096227356df0 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 15449173 15457885 |
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DOI: | 10.1371/journal.pbio.3002029 |