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A chemocentric approach to the identification of cancer targets.

التفاصيل البيبلوغرافية
العنوان: A chemocentric approach to the identification of cancer targets.
المؤلفون: Beáta Flachner, Zsolt Lörincz, Angelo Carotti, Orazio Nicolotti, Praveena Kuchipudi, Nikita Remez, Ferran Sanz, József Tóvári, Miklós J Szabó, Béla Bertók, Sándor Cseh, Jordi Mestres, György Dormán
المصدر: PLoS ONE, Vol 7, Iss 4, p e35582 (2012)
بيانات النشر: Public Library of Science (PLoS), 2012.
سنة النشر: 2012
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: A novel chemocentric approach to identifying cancer-relevant targets is introduced. Starting with a large chemical collection, the strategy uses the list of small molecule hits arising from a differential cytotoxicity screening on tumor HCT116 and normal MRC-5 cell lines to identify proteins associated with cancer emerging from a differential virtual target profiling of the most selective compounds detected in both cell lines. It is shown that this smart combination of differential in vitro and in silico screenings (DIVISS) is capable of detecting a list of proteins that are already well accepted cancer drug targets, while complementing it with additional proteins that, targeted selectively or in combination with others, could lead to synergistic benefits for cancer therapeutics. The complete list of 115 proteins identified as being hit uniquely by compounds showing selective antiproliferative effects for tumor cell lines is provided.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC3338416?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0035582
URL الوصول: https://doaj.org/article/3723a4fc6cdc46bd98dc182350806210
رقم الأكسشن: edsdoj.3723a4fc6cdc46bd98dc182350806210
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0035582