دورية أكاديمية
Efficacy of intestinal microorganisms on immunotherapy of non-small cell lung cancer
| العنوان: | Efficacy of intestinal microorganisms on immunotherapy of non-small cell lung cancer |
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| المؤلفون: | Hua Xu, Yongchun Deng, Qing Zhu, Feng Li, Na Liu, Jun Cheng, Min Qiu |
| المصدر: | Heliyon, Vol 10, Iss 9, Pp e29899- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
| مصطلحات موضوعية: | Non-small cell lung cancer, Immunotherapy, 16s rRNA, Intestinal microorganisms, Biomarker, Science (General), Q1-390, Social sciences (General), H1-99 |
| الوصف: | While the 5-year survival rate of patients with advanced non-small cell lung cancer (NSCLC) has seen some improvement, the majority of NSCLC patients fail to respond to immunotherapy with immune checkpoint inhibitors (ICIs). It is critical to identify effective biomarkers that can enhance the efficacy of immunotherapy. The clinical data in the current study were collected from NSCLC patients treated with ICIs, and two groups were classified according to treatment effect: good group with consistent efficacy, poor group with only progressiveness. Differences in intestinal microbiota between the two groups were analyzed using 16s rRNA sequencing. Beta diversity analysis indicated differences between the two groups that were available for differentiation. Comparison of the number of common or unique operational taxonomic units (OTUs) among different groups suggested that there were 53 unique OTUs in the good group and 51 unique OTUs in the poor group. At the phylum level, there was a difference between the two groups for several bacterial groups with the highest abundance values, among which Firmicutes, Actinobacteria and Fusobacteria were more abundant in the good group. Members of the genera Bifidobacterium and Lactobacillus were abundant in the good group, while the abundance of Bacteroides was low. Biomarkers in the poor group included Bacteroides, Bacteroidetes, Bacteroidia, Bacteroidales, Bacteroidaceae and Veillonellaceae. The intestinal microbiota composition affected the immunotherapy process for NSCLC, which might offer more rational instructions for the clinical application of ICIs in NSCLC patients. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405844024059309; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2024.e29899 |
| URL الوصول: | https://doaj.org/article/373ac6e265814a0face0247362ce1a18 |
| رقم الأكسشن: | edsdoj.373ac6e265814a0face0247362ce1a18 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2024.e29899 |