دورية أكاديمية
أعرض في EDS

Modeling the impact of thoracic pressure on intracranial pressure

التفاصيل البيبلوغرافية
العنوان: Modeling the impact of thoracic pressure on intracranial pressure
المؤلفون: Drayton W. Munster, Beth E. Lewandowski, Emily S. Nelson, R. K. Prabhu, Jerry G. Myers Jr
المصدر: npj Microgravity, Vol 10, Iss 1, Pp 1-10 (2024)
بيانات النشر: Nature Portfolio, 2024.
سنة النشر: 2024
المجموعة: LCC:Biotechnology
LCC:Physiology
مصطلحات موضوعية: Biotechnology, TP248.13-248.65, Physiology, QP1-981
الوصف: Abstract A potential contribution to the progression of Spaceflight Associated Neuro-ocular Syndrome is the thoracic-to-spinal dural sac transmural pressure relationship. In this study, we utilize a lumped-parameter computational model of human cerebrospinal fluid (CSF) systems to investigate mechanisms of CSF redistribution. We present two analyses to illustrate potential mechanisms for CSF pressure alterations similar to those observed in microgravity conditions. Our numerical evidence suggests that the compliant relationship between thoracic and CSF compartments is insufficient to solely explain the observed decrease in CSF pressure with respect to the supine position. Our analyses suggest that the interaction between thoracic pressure and the cardiovascular system, particularly the central veins, has greater influence on CSF pressure. These results indicate that future studies should focus on the holistic system, with the impact of cardiovascular changes to the CSF pressure emphasized over the sequestration of fluid in the spine.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2373-8065
Relation: https://doaj.org/toc/2373-8065
DOI: 10.1038/s41526-024-00385-5
URL الوصول: https://doaj.org/article/37509d94e50940c093374389300cabf9
رقم الأكسشن: edsdoj.37509d94e50940c093374389300cabf9
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23738065
DOI:10.1038/s41526-024-00385-5