دورية أكاديمية
أعرض في EDS

Changes in Serum Creatinine Levels Can Help Distinguish Hypovolemic from Euvolemic Hyponatremia

التفاصيل البيبلوغرافية
العنوان: Changes in Serum Creatinine Levels Can Help Distinguish Hypovolemic from Euvolemic Hyponatremia
المؤلفون: Jorge Gabriel Ruiz-Sánchez, Martín Cuesta, Emilia Gómez-Hoyos, Jersy Cárdenas-Salas, Miguel Ángel Rubio-Herrera, Estefanía Martínez-González, Paz De Miguel Novoa, Jara Eloisa Ternero-Vega, Alfonso Luis Calle-Pascual, Isabelle Runkle
المصدر: Medicina, Vol 58, Iss 7, p 851 (2022)
بيانات النشر: MDPI AG, 2022.
سنة النشر: 2022
المجموعة: LCC:Medicine (General)
مصطلحات موضوعية: hyponatremia, hypovolemic hyponatremia, euvolemic hyponatremia, SIAD, serum creatinine, Medicine (General), R5-920
الوصف: Background and Objectives: Differentiating between hypovolemic (HH) and euvolemic hyponatremia (EH) is crucial for correct diagnosis and therapy, but can be a challenge. We aim to ascertain whether changes in serum creatinine (SC) can be helpful in distinguishing HH from EH. Materials and Methods: Retrospective analysis of patients followed in a monographic hyponatremia outpatient clinic of a tertiary hospital during 1 January 2014–30 November 2019. SC changes during HH and EH from eunatremia were studied. The diagnostic accuracy of the SC change from eunatremia to hyponatremia (∆SC) was analyzed. Results: A total of 122 hyponatremic patients, median age 79 years (70–85), 46.7% women. In total, 70/122 patients had EH, 52/122 HH. During hyponatremia, median SC levels increased in the HH group: +0.18 mg/dL [0.09–0.39, p < 0.001], but decreased in the EH group: −0.07 mg/dL (−0.15–0.02, p < 0.001), as compared to SC in eunatremia. HH subjects presented a higher rate of a positive ∆SC than EH (90.4% vs. 25.7%, p < 0.001). EH subjects presented a higher rate of a negative/null ∆SC than HH (74.3% vs. 9.6%, p < 0.001). ROC curve analysis found an AUC of 0.908 (95%CI: 0.853 to 0.962, p < 0.001) for ∆SC%. A ∆SC% ≥ 10% had an OR of 29.0 (95%CI: 10.3 to 81.7, p < 0.001) for HH. A ∆SC% ≤ 3% had an OR of 68.3 (95%CI: 13.0 to 262.2, p < 0.001) for EH. Conclusions: The assessment of SC changes from eunatremia to hyponatremia can be useful in distinguishing between HH and EH.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1648-9144
1010-660X
Relation: https://www.mdpi.com/1648-9144/58/7/851; https://doaj.org/toc/1010-660X; https://doaj.org/toc/1648-9144
DOI: 10.3390/medicina58070851
URL الوصول: https://doaj.org/article/3761671d40034150b8aabbee66a818f8
رقم الأكسشن: edsdoj.3761671d40034150b8aabbee66a818f8
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:16489144
1010660X
DOI:10.3390/medicina58070851