دورية أكاديمية
A potential risk factor of essential hypertension in case-control study: MicroRNAs miR-10a-5p
| العنوان: | A potential risk factor of essential hypertension in case-control study: MicroRNAs miR-10a-5p |
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| المؤلفون: | Yizhe Luo, Xingjie Bao, Shuying Zheng, Tianlun Gu, Shuqi Mao, Shike Liu, Jihan Sun, Mengyi Huang, Lina Zhang |
| المصدر: | Clinical and Experimental Hypertension, Vol 42, Iss 1, Pp 36-42 (2020) |
| بيانات النشر: | Taylor & Francis Group, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: | micrornas, biomarker, essential hypertension, gene expression mir-10a-5p, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Background: Essential hypertension is a multifactorial disease with high morbidity. The researches on the influence of genes on the disease are still in its infancy, and the mechanism of gene regulation is not clear. MiRNAs are key molecules that regulate the expression control of protein-coding or protein-non-coding RNA. It may be an important biological molecule risk factor for essential hypertension. Methods: A case-control study with 98 EH and 98 non-EH was conducted in our experiment. The candidate miRNAs including miR-10a-5p and miR-497-5p were detected and verified by qRT-PCR. Results: The expression level of miRNA in EH cases was significantly lower than the healthy control (P = 0.005). In addition, the relative expression of miR-10a-5p was closely positive correlated with DBP (r = 0.162, P = 0.023) and SBP (r = 0.223, P = 0.002). After adjusting confound factors, the result of the logistic regression indicated that hypo-expression of miR-10a-5p is a risk factor for EH (OR(95%CI) = 1.676(1.302,2.157), adjusted P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1064-1963 1525-6006 10641963 |
| Relation: | https://doaj.org/toc/1064-1963; https://doaj.org/toc/1525-6006 |
| DOI: | 10.1080/10641963.2019.1571597 |
| URL الوصول: | https://doaj.org/article/a378428d8f77456fb6f565881252d229 |
| رقم الأكسشن: | edsdoj.378428d8f77456fb6f565881252d229 |
| قاعدة البيانات: | Directory of Open Access Journals |
PDF full text from Publisher | تدمد: | 10641963 15256006 |
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| DOI: | 10.1080/10641963.2019.1571597 |