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The anti-angiogenic tyrosine kinase inhibitor Pazopanib kills cancer cells and disrupts endothelial networks in biomimetic three-dimensional renal tumouroids

التفاصيل البيبلوغرافية
العنوان: The anti-angiogenic tyrosine kinase inhibitor Pazopanib kills cancer cells and disrupts endothelial networks in biomimetic three-dimensional renal tumouroids
المؤلفون: Katerina Stamati, Patricia A Redondo, Agata Nyga, Joana B Neves, Maxine GB Tran, Mark Emberton, Umber Cheema, Marilena Loizidou
المصدر: Journal of Tissue Engineering, Vol 11 (2020)
بيانات النشر: SAGE Publishing, 2020.
سنة النشر: 2020
المجموعة: LCC:Biochemistry
مصطلحات موضوعية: Biochemistry, QD415-436
الوصف: Pazopanib is a tyrosine kinase inhibitor used to treat renal cell carcinoma. Few in vitro studies investigate its effects towards cancer cells or endothelial cells in the presence of cancer. We tested the effect of Pazopanib on renal cell carcinoma cells (CAKI-2,786-O) in two-dimensional and three-dimensional tumouroids made of dense extracellular matrix, treated in normoxia and hypoxia. Finally, we engineered complex tumouroids with a stromal compartment containing fibroblasts and endothelial cells. Simple CAKI-2 tumouroids were more resistant to Pazopanib than 786-O tumouroids. Under hypoxia, while the more ‘resistant’ CAKI-2 tumouroids showed no decrease in viability, 786-O tumouroids required higher Pazopanib concentrations to induce cell death. In complex tumouroids, Pazopanib exposure led to a reduction in the overall cell viability (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2041-7314
20417314
Relation: https://doaj.org/toc/2041-7314
DOI: 10.1177/2041731420920597
URL الوصول: https://doaj.org/article/ee3795e876754f4fa91d5b941fc49b03
رقم الأكسشن: edsdoj.3795e876754f4fa91d5b941fc49b03
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20417314
DOI:10.1177/2041731420920597