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Comparison between a novel salivary marker and several clinical prognosticators in oral cavity cancer

التفاصيل البيبلوغرافية
العنوان: Comparison between a novel salivary marker and several clinical prognosticators in oral cavity cancer
المؤلفون: Yi‐Chan Lee, Li‐Yu Lee, Yenlin Huang, Huang‐Kai Kao, Ya‐Ting Chang, Shao‐Yu Hung, Chuieng‐Yi Lu, Yu‐Sun Chang, Jau‐Song Yu, Kai‐Ping Chang
المصدر: Laryngoscope Investigative Otolaryngology, Vol 8, Iss 6, Pp 1547-1556 (2023)
بيانات النشر: Wiley, 2023.
سنة النشر: 2023
المجموعة: LCC:Otorhinolaryngology
LCC:Surgery
مصطلحات موضوعية: matrix metalloproteinase‐1, oral squamous cell carcinoma, saliva, Otorhinolaryngology, RF1-547, Surgery, RD1-811
الوصف: Abstract Objectives This study aimed to investigate the association between salivary matrix metalloproteinase‐1 (MMP‐1) and clinicopathological parameters of oral cavity squamous cell carcinoma (OSCC) and compare the prognostic efficacy of salivary MMP‐1 and other established circulating markers for OSCC. Methods Saliva specimens from 479 OSCC subjects were examined using an enzyme‐linked immunosorbent assay. The area under the curve (AUC) values of salivary MMP‐1 and other markers were calculated, and survival analyses were conducted using Kaplan–Meier and multivariate regression methods. Results Salivary MMP‐1 showed good discrimination in predicting overall survival, with an AUC of 0.638, which was significantly higher than that of albumin (0.530, p = .021) and Charlson comorbidity index (0.568, p = .048) and comparable with neutrophil‐to‐lymphocyte ratio (0.620, p = .987), platelet‐to‐lymphocyte ratio (0.575, p = .125), and squamous cell carcinoma antigen (0.609, p = .605). Elevated levels of salivary MMP‐1 were significantly associated with higher pT classification, pN classification, overall pathological stage, positive extranodal extension, tumor differentiation, positive lymphovascular invasion, positive perineural invasion, and tumor depth (p all
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2378-8038
Relation: https://doaj.org/toc/2378-8038
DOI: 10.1002/lio2.1166
URL الوصول: https://doaj.org/article/37a98db104df46c6972d2329398a7fbf
رقم الأكسشن: edsdoj.37a98db104df46c6972d2329398a7fbf
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23788038
DOI:10.1002/lio2.1166