دورية أكاديمية
Increasing incidence of Type 1 diabetes – role for genes?
| العنوان: | Increasing incidence of Type 1 diabetes – role for genes? |
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| المؤلفون: | Onkamo Päivi, Pitkäniemi Janne, Tuomilehto Jaakko, Arjas Elja |
| المصدر: | BMC Genetics, Vol 5, Iss 1, p 5 (2004) |
| بيانات النشر: | BMC, 2004. |
| سنة النشر: | 2004 |
| المجموعة: | LCC:Genetics |
| مصطلحات موضوعية: | Genetics, QH426-470 |
| الوصف: | Abstract Background The incidence of Type 1 diabetes (T1DM) is increasing fast in many populations. The reasons for this are not known, although an increase in the penetrance of the diabetes-associated alleles, through changes in the environment, might be the most plausible mechanism. After the introduction of insulin treatment in 1930s, an increase in the pool of genetically susceptible individuals has been suggested to contribute to the increase in the incidence of Type 1 diabetes. Results To explore this hypothesis, the authors formulate a simple population genetic model for the incidence change driven by non-Mendelian transmission of a single susceptibility factor, either allele(s) or haplotype(s). A Poisson mixture model is used to model the observed number of cases. Model parameters were estimated by maximizing the log-likelihood function. Based on the Finnish incidence data 1965–1996 the point estimate of the transmission probability was 0.998. Given our current knowledge of the penetrance of the most diabetic gene variants in the HLA region and their transmission probabilities, this value is exceedingly unrealistic. Conclusions As a consequence, non-Mendelian transmission of diabetic allele(s)/haplotype(s) if present, could explain only a small part of the increase in incidence in Finland. Hence, the importance of other, probably environmental factors modifying the disease incidence is emphasized. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1471-2156 03277542 |
| Relation: | http://www.biomedcentral.com/1471-2156/5/5; https://doaj.org/toc/1471-2156 |
| DOI: | 10.1186/1471-2156-5-5 |
| URL الوصول: | https://doaj.org/article/d37e2b03277542398a16f952c7b20dfa |
| رقم الأكسشن: | edsdoj.37e2b03277542398a16f952c7b20dfa |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 14712156 03277542 |
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| DOI: | 10.1186/1471-2156-5-5 |