Alopecia areata patients show deficiency of FOXP3+CD39+ T regulatory cells and clonotypic restriction of Treg TCRβ-chain, which highlights the immunopathological aspect of the disease.

التفاصيل البيبلوغرافية
العنوان:	Alopecia areata patients show deficiency of FOXP3+CD39+ T regulatory cells and clonotypic restriction of Treg TCRβ-chain, which highlights the immunopathological aspect of the disease.
المؤلفون:	Fatma N Hamed, Annika Åstrand, Marta Bertolini, Alfredo Rossi, Afsaneh Maleki-Dizaji, Andrew G Messenger, Andrew J G McDonagh, Rachid Tazi-Ahnini
المصدر:	PLoS ONE, Vol 14, Iss 7, p e0210308 (2019)
بيانات النشر:	Public Library of Science (PLoS), 2019.
سنة النشر:	2019
المجموعة:	LCC:Medicine LCC:Science
مصطلحات موضوعية:	Medicine, Science
الوصف:	Alopecia areata (AA) is a hair loss disorder resulting from an autoimmune reaction against hair follicles. T-helper 1 cells are a major contributor to this disorder, but little is known about the role of T-regulatory cells (Tregs) in AA. Here, we analysed the distribution of circulating Treg subsets in twenty AA patients with active hair loss and fifteen healthy subjects by flow cytometry. The Treg suppressor HLA-DR+ subpopulation was significantly reduced in the patients (P
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	1932-6203
Relation:	https://doaj.org/toc/1932-6203
DOI:	10.1371/journal.pone.0210308
URL الوصول:	https://doaj.org/article/c382d8d79038439b8eb2a74cb2728085
رقم الأكسشن:	edsdoj.382d8d79038439b8eb2a74cb2728085
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	19326203
DOI:	10.1371/journal.pone.0210308