دورية أكاديمية
Pursuing Intracellular Pathogens with Hyaluronan. From a ‘Pro-Infection’ Polymer to a Biomaterial for ‘Trojan Horse’ Systems
| العنوان: | Pursuing Intracellular Pathogens with Hyaluronan. From a ‘Pro-Infection’ Polymer to a Biomaterial for ‘Trojan Horse’ Systems |
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| المؤلفون: | Elita Montanari, Chiara Di Meo, Angela Oates, Tommasina Coviello, Pietro Matricardi |
| المصدر: | Molecules, Vol 23, Iss 4, p 939 (2018) |
| بيانات النشر: | MDPI AG, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Organic chemistry |
| مصطلحات موضوعية: | hyaluronan, intracellular infections, CD44, nano-carriers, antimicrobial delivery, Organic chemistry, QD241-441 |
| الوصف: | Hyaluronan (HA) is among the most important bioactive polymers in mammals, playing a key role in a number of biological functions. In the last decades, it has been increasingly studied as a biomaterial for drug delivery systems, thanks to its physico-chemical features and ability to target and enter certain cells. The most important receptor of HA is ‘Cluster of Differentiation 44’ (CD44), a cell surface glycoprotein over-expressed by a number of cancers and heavily involved in HA endocytosis. Moreover, CD44 is highly expressed by keratinocytes, activated macrophages and fibroblasts, all of which can act as ‘reservoirs’ for intracellular pathogens. Interestingly, both CD44 and HA appear to play a key role for the invasion and persistence of such microorganisms within the cells. As such, HA is increasingly recognised as a potential target for nano-carriers development, to pursuit and target intracellular pathogens, acting as a ‘Trojan Horse’. This review describes the biological relationship between HA, CD44 and the entry and survival of a number of pathogens within the cells and the subsequent development of HA-based nano-carriers for enhancing the intracellular activity of antimicrobials. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1420-3049 23040939 |
| Relation: | http://www.mdpi.com/1420-3049/23/4/939; https://doaj.org/toc/1420-3049 |
| DOI: | 10.3390/molecules23040939 |
| URL الوصول: | https://doaj.org/article/a386a3caab0540cfbf87adb417e83f00 |
| رقم الأكسشن: | edsdoj.386a3caab0540cfbf87adb417e83f00 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14203049 23040939 |
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| DOI: | 10.3390/molecules23040939 |