دورية أكاديمية
Gene enrichment analysis and protein–protein interaction network topology delineates S-Phase kinase-associated protein 1 and catenin beta-1 as potential signature genes linked to glioblastoma prognosis
| العنوان: | Gene enrichment analysis and protein–protein interaction network topology delineates S-Phase kinase-associated protein 1 and catenin beta-1 as potential signature genes linked to glioblastoma prognosis |
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| المؤلفون: | K Ashwini, Pavan Gollapalli, Shilpa S Shetty, Ananthan Raghotham, Praveenkumar Shetty, Jayaprakash Shetty, N Suchetha Kumari |
| المصدر: | Biomedical and Biotechnology Research Journal, Vol 7, Iss 1, Pp 37-47 (2023) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biotechnology |
| مصطلحات موضوعية: | catenin beta-1, gene ontology, glioblastoma, protein–protein interaction, s-phase kinase associated protein 1, Biotechnology, TP248.13-248.65 |
| الوصف: | Background: Glioblastoma (GBM) is the most malignant and accounts for 60% of brain tumors in adults. Current therapy for GBM involves surgical removal of the tumor followed by radiotherapy with concomitant adjuvant therapy temozolomide. Despite improvements in therapy, patient survival remains low. The exact etiology of a brain tumor is uncertain, and numerous unknown genes are involved in the progression of GBM. The aim of the present study was to evaluate various genes involved in GBM through bioinformatic approach. Methods: In the present study, gene expression profile of GSE68424 was retrieved from the GEO database to explore the genes in GBM. Results: Analysis of expression profile data revealed that 33 genes were upregulated and 1189 genes were downregulated based on the log2 fold change cut-off criteria. The genes S-Phase kinase-associated protein 1 (SKP1) and Catenin beta-1 (CTNNB1) have been linked to GBM prognosis. Conclusion: SKP1 and CTNNB1 were identified as a candidate gene for GBM study as a result of these findings. Catenin beta-1 was the protein with the highest closeness centrality value and is the key component of canonical Wnt signaling downstream pathway. More study is needed to establish the molecular function of SKP1 and CTNNB1 in GBM development, as well as the biomarker's specificity and sensitivity. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2588-9834 2588-9842 |
| Relation: | http://www.bmbtrj.org/article.asp?issn=2588-9834;year=2023;volume=7;issue=1;spage=37;epage=47;aulast=Ashwini; https://doaj.org/toc/2588-9834; https://doaj.org/toc/2588-9842 |
| DOI: | 10.4103/bbrj.bbrj_344_22 |
| URL الوصول: | https://doaj.org/article/387a87adc6664217a804a438f7044743 |
| رقم الأكسشن: | edsdoj.387a87adc6664217a804a438f7044743 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 25889834 25889842 |
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| DOI: | 10.4103/bbrj.bbrj_344_22 |