دورية أكاديمية
Structural and Functional Enrichment Analyses for Antimicrobial Peptides
| العنوان: | Structural and Functional Enrichment Analyses for Antimicrobial Peptides |
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| المؤلفون: | Sheng C. Lo, Zhong-Ru Xie, Kuan Y. Chang |
| المصدر: | International Journal of Molecular Sciences, Vol 21, Iss 22, p 8783 (2020) |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | structure–function relationships, enrichment analysis, antifungal activities, knottin, two-layer sandwich architecture, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Whether there is any inclination between structures and functions of antimicrobial peptides (AMPs) is a mystery yet to be unraveled. AMPs have various structures associated with many different antimicrobial functions, including antibacterial, anticancer, antifungal, antiparasitic and antiviral activities. However, none has yet reported any antimicrobial functional tendency within a specific category of protein/peptide structures nor any structural tendency of a specific antimicrobial function with respect to AMPs. Here, we examine the relationships between structures categorized by three structural classification methods (CATH, SCOP, and TM) and seven antimicrobial functions with respect to AMPs using an enrichment analysis. The results show that antifungal activities of AMPs were tightly related to the two-layer sandwich structure of CATH, the knottin fold of SCOP, and the first structural cluster of TM. The associations with knottin and TM Cluster 1 even sustained through the AMPs with a low sequence identity. Moreover, another significant mutual enrichment was observed between the third cluster of TM and anti-Gram-positive-bacterial/anti-Gram-negative-bacterial activities. The findings of the structure–function inclination further our understanding of AMPs and could help us design or discover new therapeutic potential AMPs. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/21/22/8783; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms21228783 |
| URL الوصول: | https://doaj.org/article/38a625b51b6840bc8a7a4854903a1f8a |
| رقم الأكسشن: | edsdoj.38a625b51b6840bc8a7a4854903a1f8a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms21228783 |