دورية أكاديمية
Older Age Is Associated with Decreased Levels of VDR, CYP27B1, and CYP24A1 and Increased Levels of PTH in Human Parathyroid Glands
العنوان: | Older Age Is Associated with Decreased Levels of VDR, CYP27B1, and CYP24A1 and Increased Levels of PTH in Human Parathyroid Glands |
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المؤلفون: | Yi Jiang, Liyan Liao, Jina Li, Larry Wang, Zhongjian Xie |
المصدر: | International Journal of Endocrinology, Vol 2020 (2020) |
بيانات النشر: | Wiley, 2020. |
سنة النشر: | 2020 |
المجموعة: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
مصطلحات موضوعية: | Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
الوصف: | Parathyroid glands contain the vitamin D receptor (VDR) and 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) and 24-hydroxylase (CYP24A1), which catalyze the production and degradation of 1,25-dihydroxyvitamin D [1,25(OH)2D], respectively. Previous studies have shown that the serum level of intact parathyroid hormone (iPTH) increases with age. We hypothesized that the expression of CYP27B1 or VDR in parathyroid glands decreases with age, which might account for the increased serum levels of iPTH due to decreased suppression of parathyroid hormone (PTH) secretion by 1,25(OH)2D in older people. To test this hypothesis, we examined relative expression levels of VDR, CYP27B1, CYP24A1, and PTH in specimens from parathyroid glands unintentionally removed during thyroidectomy for 70 patients varying in age from 10 to 70 years. The results showed that there was an inverse correlation between age and VDR, CYP27B1, and CYP24A1 expression (p |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1687-8337 1687-8345 |
Relation: | https://doaj.org/toc/1687-8337; https://doaj.org/toc/1687-8345 |
DOI: | 10.1155/2020/7257913 |
URL الوصول: | https://doaj.org/article/d38a71c3e0c54d0089690dbcea5d2ceb |
رقم الأكسشن: | edsdoj.38a71c3e0c54d0089690dbcea5d2ceb |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 16878337 16878345 |
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DOI: | 10.1155/2020/7257913 |