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Older Age Is Associated with Decreased Levels of VDR, CYP27B1, and CYP24A1 and Increased Levels of PTH in Human Parathyroid Glands

التفاصيل البيبلوغرافية
العنوان: Older Age Is Associated with Decreased Levels of VDR, CYP27B1, and CYP24A1 and Increased Levels of PTH in Human Parathyroid Glands
المؤلفون: Yi Jiang, Liyan Liao, Jina Li, Larry Wang, Zhongjian Xie
المصدر: International Journal of Endocrinology, Vol 2020 (2020)
بيانات النشر: Wiley, 2020.
سنة النشر: 2020
المجموعة: LCC:Diseases of the endocrine glands. Clinical endocrinology
مصطلحات موضوعية: Diseases of the endocrine glands. Clinical endocrinology, RC648-665
الوصف: Parathyroid glands contain the vitamin D receptor (VDR) and 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) and 24-hydroxylase (CYP24A1), which catalyze the production and degradation of 1,25-dihydroxyvitamin D [1,25(OH)2D], respectively. Previous studies have shown that the serum level of intact parathyroid hormone (iPTH) increases with age. We hypothesized that the expression of CYP27B1 or VDR in parathyroid glands decreases with age, which might account for the increased serum levels of iPTH due to decreased suppression of parathyroid hormone (PTH) secretion by 1,25(OH)2D in older people. To test this hypothesis, we examined relative expression levels of VDR, CYP27B1, CYP24A1, and PTH in specimens from parathyroid glands unintentionally removed during thyroidectomy for 70 patients varying in age from 10 to 70 years. The results showed that there was an inverse correlation between age and VDR, CYP27B1, and CYP24A1 expression (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1687-8337
1687-8345
Relation: https://doaj.org/toc/1687-8337; https://doaj.org/toc/1687-8345
DOI: 10.1155/2020/7257913
URL الوصول: https://doaj.org/article/d38a71c3e0c54d0089690dbcea5d2ceb
رقم الأكسشن: edsdoj.38a71c3e0c54d0089690dbcea5d2ceb
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:16878337
16878345
DOI:10.1155/2020/7257913