دورية أكاديمية
Prevention and Control of Infections in Patients with Severe Congenital Neutropenia; A Follow up Study
| العنوان: | Prevention and Control of Infections in Patients with Severe Congenital Neutropenia; A Follow up Study |
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| المؤلفون: | Tahmineh Salehi, Mohammad Reza Fazlollahi, Marzieh Maddah, Mohsen Nayebpour, Mojtaba Tabatabaei Yazdi, Zahra Alizadeh, Peyman Eshghi, Zahra Chavoshzadeh, Masoud Movahedi, Amir Ali Hamidieh, Taher Cheraghi, Zahra Pourpak, Mostafa Moin |
| المصدر: | Iranian Journal of Allergy, Asthma and Immunology, Vol 11, Iss 1 (2012) |
| بيانات النشر: | Tehran University of Medical Sciences, 2012. |
| سنة النشر: | 2012 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | GCSF, Immunodeficiency, Neutropenia, Severe Congenital Neutropenia, Medicine |
| الوصف: | Severe Congenital Neutropenia is one of primary immunodeficiency disorders that characterized by severe neutropenia and is associated with severe systemic bacterial infections from early infancy. Granulocyte Colony Stimulating Factor (GCSF) is clinically used as a treatment for congenital and acquired neutropenia. The aim of this study was evaluation of GCSF (PD- Grastim) in treatment of these patients. Patients with severe congenital neutropenia referred to Immunology, Asthma and Allergy Research Institute between Jan 2007 and Dec 2010 enrolled the study. Other causes of neutropenia were excluded by serial CBC and bone marrow studies, medical and drug histories and immunological tests. Patients were visited and examined monthly to evaluate their CBC and ANC (Absolute Neutrophil Count), GCSF side effects and dosage adjustment. Cytogenetic studies were being done for all the patients for early detection of progression to AML/MDS. From twenty two patients who enrolled this study, 16 patients regularly evaluated. They were ten males and six females, range in age from 2 to 18 years old. Two patients failed to continue our follow up unfortunately and four patients died due to disease complications. Patients were followed for 24 to 48 months. In a period of 12-24 months before treatment, the mean of hospitalization frequency was 3.1 times and duration was 10 days; while during receiving treatment, they decreased to 0.2 times and 3 days, respectively (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1735-1502 1735-5249 |
| Relation: | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/330; https://doaj.org/toc/1735-1502; https://doaj.org/toc/1735-5249 |
| URL الوصول: | https://doaj.org/article/38b2e5298f76452bbd4519ac8ac4ab9e |
| رقم الأكسشن: | edsdoj.38b2e5298f76452bbd4519ac8ac4ab9e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17351502 17355249 |
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