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Modeling of cognitive impairment by disease duration in multiple sclerosis: a cross-sectional study.

التفاصيل البيبلوغرافية
العنوان: Modeling of cognitive impairment by disease duration in multiple sclerosis: a cross-sectional study.
المؤلفون: Anat Achiron, Joab Chapman, David Magalashvili, Mark Dolev, Mor Lavie, Eran Bercovich, Michael Polliack, Glen M Doniger, Yael Stern, Olga Khilkevich, Shay Menascu, Gil Hararai, Micharel Gurevich, Yoram Barak
المصدر: PLoS ONE, Vol 8, Iss 8, p e71058 (2013)
بيانات النشر: Public Library of Science (PLoS), 2013.
سنة النشر: 2013
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: BACKGROUND/AIMS: Large-scale population studies measuring rates and dynamics of cognitive decline in multiple sclerosis (MS) are lacking. In the current cross-sectional study we evaluated the patterns of cognitive impairment in MS patients with disease duration of up to 30 years. METHODS: 1,500 patients with MS were assessed by a computerized cognitive battery measuring verbal and non-verbal memory, executive function, visual spatial perception, verbal function, attention, information processing speed and motor skills. Cognitive impairment was defined as below one standard deviation (SD) and severe cognitive impairment as below 2SD for age and education matched healthy population norms. RESULTS: Cognitive performance in our cohort was poorer than healthy population norms. The most frequently impaired domains were information processing speed and executive function. MS patients with secondary-progressive disease course performed poorly compared with clinically isolated syndrome, relapsing-remitting and primary progressive MS patients. By the fifth year from disease onset, 20.9% of patients performed below the 1SD cutoff for impairment, p=0.005, and 6.0% performed below the 2SD cutoff for severe cognitive impairment, p=0.002. By 10 years from onset 29.3% and 9.0% of patients performed below the 1SD and 2SD cutoffs, respectively, p=0.0001. Regression modeling suggested that cognitive impairment may precede MS onset by 1.2 years. CONCLUSIONS: The rates of cognitive impairment in this large sample of MS patients were lower than previously reported and severe cognitive impairment was evident only in a relatively small group of patients. Cognitive impairment differed significantly from expected normal distribution only at five years from onset, suggesting the existence of a therapeutic window during which patients may benefit from interventions to maintain cognitive health.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC3731335?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0071058
URL الوصول: https://doaj.org/article/38da6b36d2a54384bcea5aaa5ec9de1e
رقم الأكسشن: edsdoj.38da6b36d2a54384bcea5aaa5ec9de1e
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0071058