دورية أكاديمية
Transpelvic Magnetic Stimulation Enhances Penile Microvascular Perfusion in a Rat Model: A Novel Interventional Strategy to Prevent Penile Fibrosis after Cavernosal Nerve Injury
| العنوان: | Transpelvic Magnetic Stimulation Enhances Penile Microvascular Perfusion in a Rat Model: A Novel Interventional Strategy to Prevent Penile Fibrosis after Cavernosal Nerve Injury |
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| المؤلفون: | Samuel Sorkhi, Christopher Cano Sanchez, Min Chul Cho, Sung Yong Cho, Hong Chung, Min Gu Park, Susan Lahey, Tung-Chin Hsieh, Valmik Bhargava, Mahadevan Raj Rajasekaran |
| المصدر: | The World Journal of Men's Health, Vol 40, Iss 3, Pp 501-508 (2022) |
| بيانات النشر: | Korean Society for Sexual Medicine and Andrology, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine LCC:Diseases of the genitourinary system. Urology |
| مصطلحات موضوعية: | elastin, erectile dysfunction, fibrosis, laser speckle contrast imaging, microcirculation, penis, Medicine, Diseases of the genitourinary system. Urology, RC870-923 |
| الوصف: | Purpose:Purpose: Penile microvascular dysfunction is a known contributor to erectile dysfunction (ED) and penile fibrosis has been shown to impair microvascular perfusion (MVP). Our objectives were to: (i) determine beneficial effects of TPMS to modulate penile MVP, (ii) determine its mechanism, (iii) evaluate impact of cavernosal nerve injury (CNI) on penile MVP, and (iv) deter-mine time-course of cavernosal tissue elastin changes after CNI in rats. Materials Materials and and Methods:Methods: Adult male rats (n=5) were anesthetized and subjected to TPMS (13%, 15%, and 17%) and MVP changes were recorded using laser speckle contrast imaging (LSCI). Another group of male rats were subjected to either bi-lateral cavernosal nerve injury (CNI; n=7) or sham surgery (n=7). After recovery, animals were monitored for MVP using LSCI before and after TPMS. Rat penile tissues were harvested and analyzed for fibrosis using a marker for elastin. Results:Results: Rat TPMS resulted in a stimulus dependent increase in MVP; maximal perfusion was observed at 17%. L-N(G)-Nitroarginine methyl ester (L-NAME) resulted in a marked decrease in TPMS induced MVP increase (393.33 AU vs. 210.67 AU). CNI resulted in 40% to 50% decrease in MVP. CNI produced a remarkable increase in elastin deposits that are notice-able throughout the cavernosal tissues post injury. Conclusions:Conclusions: TPMS is a novel and non-invasive intervention to improve penile MVP after CNI. Potential application includes treatment of ED and sexual function preservation following cancer treatment, possibly through improved penile hemodynam-ics that might help prevent penile hypoxia and fibrosis. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2287-4208 2287-4690 |
| Relation: | https://doaj.org/toc/2287-4208; https://doaj.org/toc/2287-4690 |
| DOI: | 10.5534/wjmh.210162 |
| URL الوصول: | https://doaj.org/article/a38f6d1311d2486ca317fe1f6451537d |
| رقم الأكسشن: | edsdoj.38f6d1311d2486ca317fe1f6451537d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22874208 22874690 |
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| DOI: | 10.5534/wjmh.210162 |