دورية أكاديمية
Cucumeropsis mannii reverses high-fat diet induced metabolic derangement and oxidative stress
| العنوان: | Cucumeropsis mannii reverses high-fat diet induced metabolic derangement and oxidative stress |
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| المؤلفون: | Anthony T Olofinnade, Adejoke Y Onaolapo, Azurra Stefanucci, Adriano Mollica, Olugbenga A Olowe, Olakunle J Onaolapo |
| المصدر: | Frontiers in Bioscience-Elite, Vol 13, Iss 1, Pp 54-76 (2020) |
| بيانات النشر: | IMR Press, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Environmental sciences LCC:Microbiology |
| مصطلحات موضوعية: | cucurbitaceae, dyslipidaemia, nutrition, melon, neurobehavior, phytochemistry, Environmental sciences, GE1-350, Microbiology, QR1-502 |
| الوصف: | Cucumeropsis mannii (CM) belongs to the melon family and is native to West Africa. There is a paucity of information on its medicinal or nutraceutical potential. Here, we examined the impact of CM in mice that were treated with a normal or a high fat diet (HFD). The CM extracts had a high levels of phenols, flavonoids, ascorbic acid and significant antioxidant activity. Treatment of mice with a HFD diet, led to the memory impairment. However, mice on HFD and received CM, despite increased food intake, showed a decrease in the body weight, locomotion, rearing, grooming, acetylcholinesterase activity and γ-amino butyric acid levels and anxiolysis. Also CM induced a reversal of HFD–induced changes in glucose levels, lipid peroxidation and super-oxide dismutase activity. These data show that CM leads to variable behavioural, biochemical and metabolic effects depending on the diet of animals. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1945-0494 |
| Relation: | https://www.imrpress.com/journal/FBE/13/1/10.2741/872; https://doaj.org/toc/1945-0494 |
| DOI: | 10.2741/872 |
| URL الوصول: | https://doaj.org/article/390023a387ed466dbb9c72f470e239c9 |
| رقم الأكسشن: | edsdoj.390023a387ed466dbb9c72f470e239c9 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 19450494 |
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| DOI: | 10.2741/872 |