دورية أكاديمية
Presynaptic PTPσ regulates postsynaptic NMDA receptor function through direct adhesion-independent mechanisms
| العنوان: | Presynaptic PTPσ regulates postsynaptic NMDA receptor function through direct adhesion-independent mechanisms |
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| المؤلفون: | Kyungdeok Kim, Wangyong Shin, Muwon Kang, Suho Lee, Doyoun Kim, Ryeonghwa Kang, Yewon Jung, Yisul Cho, Esther Yang, Hyun Kim, Yong Chul Bae, Eunjoon Kim |
| المصدر: | eLife, Vol 9 (2020) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | synaptic adhesion, nmda receptors, synaptic plasticity, long-term potentiation, tyrosine phosphatase, novelty recognition, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | Synaptic adhesion molecules regulate synapse development and function. However, whether and how presynaptic adhesion molecules regulate postsynaptic NMDAR function remains largely unclear. Presynaptic LAR family receptor tyrosine phosphatases (LAR-RPTPs) regulate synapse development through mechanisms that include trans-synaptic adhesion; however, whether they regulate postsynaptic receptor functions remains unknown. Here we report that presynaptic PTPσ, a LAR-RPTP, enhances postsynaptic NMDA receptor (NMDAR) currents and NMDAR-dependent synaptic plasticity in the hippocampus. This regulation does not involve trans-synaptic adhesions of PTPσ, suggesting that the cytoplasmic domains of PTPσ, known to have tyrosine phosphatase activity and mediate protein-protein interactions, are important. In line with this, phosphotyrosine levels of presynaptic proteins, including neurexin-1, are strongly increased in PTPσ-mutant mice. Behaviorally, PTPσ-dependent NMDAR regulation is important for social and reward-related novelty recognition. These results suggest that presynaptic PTPσ regulates postsynaptic NMDAR function through trans-synaptic and direct adhesion-independent mechanisms and novelty recognition in social and reward contexts. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| Relation: | https://elifesciences.org/articles/54224; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.54224 |
| URL الوصول: | https://doaj.org/article/392bae0356a04a2fb734b61ed90253a8 |
| رقم الأكسشن: | edsdoj.392bae0356a04a2fb734b61ed90253a8 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.54224 |